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白藜芦醇对女性慢性阻塞性肺疾病患者肺功能、血清TNF-α和IL-8的影响 被引量：1

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摘要 目的探讨白藜芦醇对女性慢性阻塞性肺疾病(COPD)患者肺功能、血清肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)的影响,为女性COPD的治疗找到新的突破。方法将160例女性COPD患者分成观察组及对照组,观察组给予白藜芦醇(由白藜芦醇、乳糖、预胶化淀粉、硬脂酸镁为主要原料制成的片剂0.4 g/片,每100 g含白藜芦醇1.88 g),对照组口服安慰剂(成分为乳糖和淀粉),疗程同观察组。8个月后测定两组的血清TNF-α、IL-8。结果观察组肺功能,包括第1秒用力呼气容量、用力肺活量、1秒率肺功能和最大通气量、残气占肺总量的百分比均较治疗前有所改善,差异有统计学意义(P<0.05);观察组血清TNF-α和IL-8均较对照组降低,差异有统计学意义(P<0.05)。结论女性COPD患者长期口服白藜芦醇可有效改善肺功能,并能够降低血清TNF-α和IL-8含量。
作者 刘志敏 桑丽丽 孙鹏 刘哲慧 胥庆华
机构地区 山东省聊城市人民医院干部保健病房
出处 《广东医学》 CAS 北大核心 2015年第16期2531-2533,共3页 Guangdong Medical Journal
关键词 慢性阻塞性肺疾病 白藜芦醇 肺功能 肿瘤坏死因子-α 白细胞介素-8 女性
分类号 R563.05 [医药卫生—呼吸系统]
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参考文献15

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二级参考文献86

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广东医学
2015年 第16期

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