摘要
目的观察来曲唑治疗男性青春期乳房发育症的临床疗效及对性激素水平的影响。方法选择医院收治的39例患者,采用随机数字表法分成观察组20例和对照组19例。对照组患者不作临床治疗,观察组患者口服来曲唑治疗6个月。结果治疗后,观察组有11例(55.00%)乳房容积缩小50%以上,平均乳房容积为(256.35±92.10)m L,对照组有4例(21.05%)乳房容积缩小50%以上,平均乳房容积为(418.14±158.34)m L,组间比较,差异有统计学意义(P<0.05);观察组患者的睾酮(T)水平上升,雌二醇(E2)、E2/T水平下降,对照组中上述3项指标均上升,组间比较,差异有统计学意义(P<0.05);两组患者促黄体生成素(LH)水平均较治疗前明显上升,但组间比较,差异无统计学意义(P<0.05);两组患者促卵泡刺激素(FSH)水平均较治疗前明显上升,且差异明显(P<0.05)。结论采用来曲唑治疗男性青春期乳房发育症,可有效调整雌激素、雄激素的比例,明显缩小乳房容积和缓解疼痛,安全性好,值得临床推广。
Objective To observe letrozole in treating the male adolescent premature thelarche and its effect on the level of sex hormone. Methods Totally 39 patients were divided into two groups according to the random number method,19 cases in the control group and 20 cases in the observation group. The control group did not receive clinical treatment,and the observation group adopted letrozole therapy for 6 months. Results After treatment,the observation group had 11 cases（55. 00%） whose breast volume decreased more than 50%,with the average breast volume （256. 35 ＆#177; 92. 10） mL,the control group had 4 cases（21. 05%）whose breast volume decreased more than 50%,with the average breast volume （418. 14 ＆#177; 158. 34）mL,it had signifiant difference between the two groups （ P ﹤ 0. 05）;the T levels increased and the E2,E2/T levels decreased in the observation group,while in the control group the three indexes were all increased,with significant differences between the two groups（ P ﹤ 0. 05）;the LH level of the two groups increased significantly,but the difference was not statistically significant（ P ﹥ 0. 05）;the FSH levels of the two groups increased after treatment, and the differences were significant（ P ﹤ 0. 05）. Conclusion Letrozole in treating male adolescent premature thelarche can effectively adjust the ratio of estrogen and androgen,alleviate breast volume and reduce pain,has good safety and is worth of clinical promotion.
出处
《中国药业》
CAS
2015年第18期68-70,共3页
China Pharmaceuticals
关键词
来曲唑
青春期
乳房发育
性激素
letrozole
adolescence
premature thelarche
sex hormone
