摘要
心室重构意味着血管壁中氧化应激水平的提高,当机体受到有害刺激时,氧化和抗氧化之间失衡,导致大量活性氧簇(ROS)的产生,加速心室重构的进展。近年来,新型抗氧化剂成为治疗或预防心室重构的靶点,观察抗氧化剂治疗在心室重构患者的长期应用是当下趋势。该文就氧化应激与心室重构之间的关系及相关药物治疗进行综述。
Ventricular remodeling means increase of oxidative stress in the vascular wall level.When the body encounters harmful stimu-li,the imbalance between oxidation and antioxidation occurs,resulting in a large number of reactive oxygen species andaccelerateingven-tricular remodeling.Recently,the new antioxidants become the targets of treatment or prevention in ventricular remodeling,therefore,the long-term use of antioxidant therapy tend to be studied among ventricular remodelingpatients.In this article the relationship between oxidative stress and ventricular remodeling and the related drug treatment were reviewed.
出处
《安徽医药》
CAS
2015年第9期1633-1636,共4页
Anhui Medical and Pharmaceutical Journal
关键词
心室重构
氧化应激
活性氧
抗氧化治疗
ventricular remodeling
oxidative stress
reactive oxygen species
antioxidant therapy
