摘要
气道重塑是支气管哮喘的重要病理特征,至今具体发生机制尚不明确。文章概述了哮喘气道重塑发生与转化生长因子-β1(transforming growth factor-β1)/Smad信号通路的关系,同时总结多种西药、中药及基因干预实验对气道重塑中TGF-β1/Smad表达的影响,以进一步了解TGF-β1/Smad影响气道重塑的作用机制所在。为将来的研究提供更合理的思路和方法,并对治疗哮喘气道重塑在微观层面提供更有效的手段。
Airway remodeling is an important pathological feature of bronchial asthma and its specific mechanism has not been clear so far. This paper provides an overview of the relationship between airway remodeling and the expression of transfor- ming growth factor （TGF） - β/Smad signal pathway. It summarizes the antagonism effects of Chinese medicine ,Western medieine and gene level intervention on expression of TGF -β/Smadin order to make better understand of the mechanism of TGF - β/Smad on airway remodeling. It might provide a more rational thinking and methods for future research.
出处
《辽宁中医杂志》
CAS
北大核心
2015年第9期1811-1813,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81173299)
