摘要
目的 探讨Endoglin标记的微血管密度计数（MVD）、肽基脯氨酰顺反异构酶（Pin1）和微管不稳定蛋白（Stathmin）在非小细胞肺癌（NSCLC）组织中的表达及与NSCLC临床病理特征的关系.方法 利用免疫组织化学方法检测42例NSCLC组织和20例癌旁组织中Endoglin标记的MVD、Pin1和Stathmin的表达.结果 Endoglin标记的MVD在NSCLC癌组织中表达强度为41.26±2.32,明显高于在癌旁组织中表达强度（23.04±1.44）,两者差异有统计学意义（P＜0.01）,Endoglin标记的MVD表达强度与NSCLC的TNM分期、淋巴结转移明显相关（P＜0.05）;Pin1在NSCLC组织中表达率明显高于癌旁组织（83.33％比25.00％,P＜0.05）,Pin1表达水平与NSCLC的TNM分期、淋巴结转移明显相关（P＜0.05）;Stathmin在NSCLC组织中表达率明显高于癌旁组织（64.29％比30.00％,P＜0.05）,Stathmin表达水平与NSCLC的组织学分化程度、TNM分期、淋巴结转移明显相关（P＜0.05）.结论 Endoglin、Pin1和Stathmin高表达与NSCLC的发生发展密切相关.
Objective To investigate the expression of microvessel density （MVD） marked with endoglin,peptidy1 proly1 cis-trans isomerase （Pin1） and stathmin in non-small cell lung carcinoma （NSCLC） and to explore its relevance to the clinicopathologic features.Methods The expression of MVD marked with endoglin,Pin1 and stathmin was detected by immunohistochemistry in 42 cases of NSCLC tissues and 20 cases of non-cancerous adjacent lung tissues.Results The expression of MVD marked with endoglin was 41.26 ± 2.32 in NSCLC tissues,and 23.04 ± 1.44 in non-cancerous adjacent lung tissues （P ＜0.01）.The expression of MVD marked with endoglin were related NSCLC to TNM stage and lymph node metastasis （P ＜ 0.05）.The expression rate of Pin1 in NSCLC tissues was higher than that in non-cancerous adjacent lung tissues （83.33％ vs.25.00％,P ＜ 0.05）.The expressions of Pin1 was related NSCLC to TNM stage and lymph node metastasis （P ＜ 0.05）.The expression rate of stathmin in NSCLC tissues was higher than that in non-cancerous adjacent lung tissues （64.29％ vs.30.00％,P ＜ 0.05）.The expressions of stathmin was related NSCLC to histologic grade,TNM stage and lymph node metastasis （P ＜0.05）.Conclusion The overexpression of endoglin,Pin1 and stathmin may play important roles in the occurrence and development of NSCLC,and they can be used as reference index of the malignant degree and poor prognosis of NSCLC.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2015年第9期2270-2272,共3页
Chinese Journal of Experimental Surgery
基金
温州市科技计划资助项目（Y20140486）
