摘要
目的：探讨血清生长分化因子-15（GDF-15冰平与急性缺血性脑卒中的相关性。方法：选取急性缺血性脑卒中（组）患者120例，健康体检者60例作为对照组，采用酶联免疫吸附法测定患者发病24h的血清GDF-15水平，观察血清GDF-15水平与神经功能缺损的相关性。同时根据3个月随访时的改良Ranking量表（MRS量表）评分将120例患者分为65例残疾者（MRS≥2分）和55例非残疾者（MRS〈2分），比较两者血清GDF-15水平的差异。结果：急性缺血性脑卒中组患荇血清GDF-15水平为1594（1128～2411）ng/L，高于对照组为656（507-764）ng／L，两组比较差异有统计学意义（P〈0．05）。急性缺血性脑卒中组患者发病24h血清GDF-15水平与美国国立卫生院卒中量表评分（神经功能缺损）旱正相关（r=0．390，P〈0．001）。根据3个月随访时应用的MRS量表i平分显示，残疾者和非残疾者在发病24h的血清GDF-15水平：残疾者12411（2188～2569）ng／L]高于非残疾者[1128（980~1597）ng／L]，两者比较差异有统计学意义（Z=-5．684，P〈0．1301）。结论：急性缺血性脑卒中患者血清GDF-15水平高于正常人，而且与美国国立卫生院卒中量表评分有关联，血清GDF-15水平高则患者预后差。
Objective： To investigate the effect of serum growth differentiation factor-15 （GDF-15） in patients with acute ischemic stroke （AIS）. Methods： Our research included 2 groups： AIS group, n=120 patients and Control group, n=60 normal subjects from regular physical examination. The serum levels of GDF-15 were examined within 24 hours of AIS attack by ELISA in both groups, the relationship between GDF-15 and the neurologic impairment was assessed. According to modified ranking scale score after 3 months follow-up study, the AIS patients were further divided into 2 sub-groups： Disabled group, the patients with MRS 〉 2, n=65 and Non-disabled group, the patients with MRS 〈 2, n=55. The GDF-15 levels were compared between 2 sub-groups. Results： GDF- 15 level in AIS group was 1594.00 （1128.00-2411.00） ng/L which was significantly higher than that in Control group 656.00 （507.00-764.00） ng/L, P〈0.05. GDF-15 level was positively related to neurologic impairment in AIS patients （1=0.390, P〈0.001）. Modified ranking scale score indicated that after 3 months of follow-up study, GDF-15 level in Disabled group was 2411 （2188-2569） ng/L which was much higher than that in Non-disabled group 1128 （980-1597） ng/L, （Z=-5.684, P〈0.001）. Conclusion： The serum level of GDF-15 was higher in AIS patients than normal subjects, it was positively related to neurologic impairment, AIS patients with higher GDF- 15 would have poor prognosis.
出处
《中国循环杂志》
CSCD
北大核心
2015年第9期872-874,共3页
Chinese Circulation Journal
基金
广西中医药管理局中医药科技专项课题(GZPT1255)
广西科技攻关课题(桂科攻1355005-4-5)
柳州市应用技术研究与开发计划项目(2013F010401)
