摘要
目的观察血清降钙素原(PCT)在评估老年重症肺炎患者30d病死率中的价值。方法选取2011年1月至2013年12月该院呼吸科及重症监护病房住院的老年重症肺炎患者132例,检测血清PCT、C-反应蛋白(CRP)水平,进行肺炎严重度指数(PSI)评分,记录治疗30d后患者的病死率。通过受试者工作特征曲线(ROC)分析PCT对30d病死率的预测价值,计算曲线下面积(AUC)。结果截至治疗30d时,有79例患者死亡,53例患者存活。死亡患者的PCT、CRP水平及PSI得分明显高于存活患者水平及得分,PCT与CRP之间不存在明显相关性,PCT与PSI之间存在明显相关性,以PCT≥2.98ng/mL为诊断分界值预测重症肺炎患者30d病死率,其AUC为0.737,和PSI的AUC(0.784)相比,差异无统计学意义(P>0.05),高于CRP的AUC(0.586)。PCT与PSI的敏感度、特异度都明显高于CRP。结论 PCT水平对老年重症肺炎患者的30d病死率有较好预测价值。
Objective To observe the serum procalcitonin （PCT） in the assessment of elderly patients with severe pneumonia in 30 d mortality value .Methods 132 cases of elderly patients with severe pneumonia were studied from January 2011 to December 2014 in department of respiration and intensive care unit of Traditional Chinese medicine Hospital of Meishan ,Compare serum procalcitonin（PCT ） ,Creactive protein （CRP） level ,pneumonia severity index （PSI） scoring record of 30 d of treatment ,the mortality of patients .By receiver operating characteristic curve （ROC） analysis of serum procalcitonin value for predicting 30 d mortality ,calculating the area under the curve （AUC） .Results By the end of 30 d of treatment ,79 patients died ,53 patients were alive .Death in patients with PCT ,CRP level and PSI score was significantly higher than the level of survival patients and score ,there is no significant correlation between PCT and CRP ,there is a significant correlation between PCT and PSI ,with PCT more than 2 .98 ng/mL diagnosis value in predicting 30 d mortality in patients with severe pneumonia ,the area under the ROC curve （AUC） was 0 .737 ,and PSI AUC （0 .784） had no significant difference when compared to CRP ,higher than that of AUC （0 .586） .PCT and PSI sensitivity ,specificity were significantly higher than that of CRP .Conclusion The level of PCT has a good predictive value for the elderly patients with severe pneumonia and 30 d mortality .
出处
《检验医学与临床》
CAS
2015年第18期2705-2707,共3页
Laboratory Medicine and Clinic
