摘要
目的了解精神分裂症住院患者合并代谢综合征与颈动脉粥样硬化的关系。方法检测150例住院精神分裂症患者腹围、血压、血糖、血脂、颈动脉B超等。结果精神分裂症患者伴发代谢综合征的占34.7%,其颈动脉IMT值、颈动脉硬化和颈动脉斑块发生率均高于不伴有代谢综合征者(P<0.01)。伴发颈动脉硬化的占42%,其年龄、总病程、腹围、收缩压、FPG、TC、LDL明显大于不伴有颈动脉硬化者(P<0.05),但两组的住院时间、舒张压、TG、HDL-C差异无统计学意义(P>0.05);伴颈动脉硬化者的中心性肥胖、IFG、高血压、低HDL-C、代谢异常聚集患病率明显高于不伴颈动脉硬化者(P<0.05)、但在高TG的患病率上差异无统计学意义(P>0.05)。年龄、代谢异常聚集与颈动脉硬化有关(回归系数分别为:1.339,1.971)。结论长期住院的慢性精神分裂症患者代谢综合征、颈动脉硬化的患病率高,代谢综合征和颈动脉硬化密切相关,代谢综合征各组分间常协同存在,并共同在动脉粥样硬化发展过程中发挥重要作用。
Objective To investigate the relationship between carotid atherosclerosis （AS）and metabolic syndrome （ MS ） in schizophrenic inpatients. Methods Abdominal circumference （ AC）, blood pressure （ BP）, fasting blood glucose （ FPG）, total cholesterol （ TC ）, triglyceride （ TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein （LDL）, B-ultrasonography in carotid artery were examined in 150 inpatients with schizophrenia. Results The prevalence of MS in schizophrenic inpatients was 34. 7%. The carotid intima-media thickness （IMT）of schizophreniapatients with MS was greater than those without MS （ P 〈 0.01 ）, and the occurrence of carotid AS and carotid plaques were higher in patients with MS than those without MS （ P 〈 0.01 ）. The prevalence of carotid AS in schizophrenic inpatients was 42%. The age, disease duration, AC, SBP, FBG, TC, LDL of patients with carotid AS were significantly greater than those without carotid AS （ P 〈 0.05 ）, but there were no significant differences in length of hospital stay, DBP, TG, HDL-C between two groups （ P 〉 0.05 ）. The prevalence of central obesity, impaired fasting glucose （ IFG）, hypertension, low HDL-C, metabolic abnormalities aggregation were significantly higher than those without carotid AS （ P 〈 0.05 ）, but there was no significant difference in prevalence of high TG （ P 〉 0.05 ）. Age and metabolic abnormalities aggregation might be the risk factors of carotid AS in this population （fl = 1. 339 and 1. 971 respectively ）. Conclusion The prevalence of MS and carotid AS is high in schizophrenia inpatients, MS and carotid AS is closely related,the components of MS often coexists, and play an important role in the development of AS.
出处
《同济大学学报（医学版）》
CAS
2015年第4期90-95,共6页
Journal of Tongji University(Medical Science)
