摘要
目的分析雄激素性秃发与动脉粥样硬化危险因素之间的相关性,探索雄激素性秃发成为动脉粥样硬化的早期预警信号的可能性。方法采用病例对照研究方法,比较62例雄激素性秃发患者与60例无秃发的健康体检者体重指数(BMI)、血压(BP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白a(Lp(a))、载脂蛋白E(ApoE)、空腹血糖(FPG)、超敏C反应蛋白(hs-CRP)等动脉粥样硬化危险因素,分析两组反应血管弹性的超声前臂反应性充血试验(FMD)、脉搏波传导速度(BaPWV)、大动脉顺应性/小动脉顺应性(C1/C2)等动脉粥样硬化早期诊断指标。结果雄激素性秃发患者BMI、BP、TC、LDL-C、TC/HDL-C、LDL-C/HDL-C、ApoB、ApoB/ApoA1及BaPWV较无秃发的健康体检者均明显增高,而FMD明显降低。结论青年男性雄激素性秃发与动脉粥样硬化之间存在一定的相关性,雄激素性秃发可能是动脉粥样硬化血管疾病早期预警信号之一。
Objective To analyze the correlation between androgenetic alopecia and atherosclerosis . Methods Blood pressure (BP), body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol ( LDL-C) , high-density lipoprotein cholesterol ( HDL-C) , TC/HDL-C, LDL-C/HDL-C, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), ApoB/ApoA1, fasting plasma glucose ( FPG) , high-sensitivity C-reactive protein ( hs-CRP) and other clinical indicators in 144 cases of young men (18-35 years) with androgenetic alopecia(case group) and 60 cases of non-bald physical examinees(control group) were detected.Flow-mediated dilatation (FMD), pulse wave velocity (BaPWV) and aorta compliance/arterial compliance ( C1/C2 ) were compared .The association between androgenetic alopecia and atherosclerosis was investigated by case-control study.Results Case group had higher BP, BMT, TC, LDL-C, TC/HDL-C, LDL-C/HDL-C, ApoB, ApoB/ApoA1, BaPWV and lower FMD than control group (P〈0.05).Conclusion There is a correlation between androgenetic alopecia and atherosclerosis in young men .
出处
《湖北科技学院学报(医学版)》
2014年第2期93-95,共3页
Journal of Hubei University of Science and Technology(Medical Sciences)
基金
广东省科技计划(2010 B 031600305)