T2DM合并慢性肾脏疾病患者血清MCP-1变化及其临床意义被引量：4

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摘要目的探讨血清单核细胞趋化蛋白-1(MCP-1)在2型糖尿病(T2DM)合并慢性肾脏疾病(CKD)发生发展中的作用。方法将179例T2DM患者根据24h尿清蛋白排泄率(UAER)分为正常清蛋白尿组(NA组)65例、微量清蛋白尿组(MA组)61例及临床清蛋白尿组(CP组)53例。另外选取健康对照者50名为对照组(NC组)。检测研究对象血清MCP-1、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肌酐(Cr)、尿素氮(BUN)、糖化血红蛋白(HbA1c);葡萄糖氧化酶法测定空腹血糖(FPG);化学发光法测定空腹胰岛素(FINS)临床指标水平,比较各组间差异。结果 NA组、MA组及CP组血清MCP-1均高于NC组(P<0.05),且各组间比较差异有统计学意义(F=128 8.0,P<0.01)。Pearson相关分析显示,血清MCP-1与SBP、DBP、BUN、Cr、UAER、TG、TC、LDL-C、HbA1c、FPG、FINS及稳态胰岛素抵抗指数(HOMA-IR)呈正相关(r=0.612、0.167、0.652、0.632、0.784、0.458、0.349、0.363、0.621、0.538、0.511、0.557,P<0.05);与HDL-C和胰岛素敏感指数(ISI)呈负相关(r=-0.338、-0.633,P<0.05)。多元线性回归分析显示,UAER、ISI、SBP、HOMA-IR、病程、HDL-C、TG是T2DM患者MCP-1的独立相关因素。结论血清MCP-1随尿蛋白严重程度而逐渐升高,可作为T2DM合并CKD诊断和病情判定的重要参考指标。

作者蒋姗姗龙艳苏珂彭鹰莫如芬黄漓莉

机构地区桂林医学院附属医院内分泌科

出处《重庆医学》 CAS 北大核心 2015年第27期3827-3829,共3页 Chongqing medicine

关键词糖尿病 2型糖尿病肾病尿清蛋白排泄率单核细胞趋化蛋白-1

分类号 R587.2 [医药卫生—内分泌] R692.9 [医药卫生—泌尿科学]

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参考文献9

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