摘要
目的探讨阿德福韦酯联合多烯磷脂酰胆碱胶囊治疗慢性乙型肝炎肝纤维化的临床疗效。方法 84例慢性乙型肝炎初治患者肝脏穿刺活检均表现为中重度肝纤维化,肝功能血清ALT水平高于正常值上限3～10倍。随机分为43例阿德福韦酯与多烯磷脂酰胆碱胶囊联合治疗组,41例单用阿德福韦酯对照组,观察48周时2组患者肝功能、血清HBV-DNA下降的水平及病理组织学分级。结果治疗48周后,治疗组肝功能、血清HBV-DNA下降的水平与对照组比较,P〈0.05,均有统计学意义;联合治疗组组织学改善优于对照组（P〈0.05）。结论阿德福韦酯联合多烯磷脂酰胆碱胶囊治疗慢性乙型肝炎优于单独使用阿德福韦酯。
Objective To investigate the clinical efficacy of adefovir dipivoxil combined with Polyene Phosphatidylcholine Capsules liver fibrosis in chronic hepatitis patients. Methods 84 cases of chronic hepatitis 13 patients with untreated liver biopsy showed moderate to severe liver fibrosis of liver function, serum ALT level higher than the upper limit of normal 3～10 times. Were randomly divided into 43 cases of adefovir Dipivoxil and Polyene Phosphatidylcholine Capsules combined treatment group, 41 cases with single adefovir dipivoxil group, observe the histopathological grade level and two groups of patients with liver function, decrease of serum HBV DNA at 48 weeks. Results After 48 weeks of treatment, the treatment group of liver function, serum HBV-DNA levels decreased compared with the control group had statistical significance （P 〈0. 05）; learn better than the control group combined treatment group （P 〈0. 05 ） tissue pathology. Conclusion Adefovir dipivoxil combined Polyene Phosphatidylcholine Capsules in treatment of chronic hepatitis B is better than single adefovir dipivoxil.
出处
《河南大学学报（医学版）》
CAS
2015年第3期192-194,共3页
Journal of Henan University:Medical Science
关键词
慢性乙型肝炎
阿德福韦酯
多烯磷脂酰胆碱胶囊
肝纤维化
chronic hepatitis B
adefovir dipivoxil
polyene phosphatidylcholine capsules
liver fibrosis
