摘要
人们一直不断探索冠心病发生发展的病理机制,积极探索易损斑块、易损病变、易损患者的识别方法,减少心血管事件。血管内超声虚拟组织学是研究冠状动脉病变特征的简单有效的手段之一。近期对于急性冠状动脉综合征的血管内超声虚拟组织学研究显示薄帽纤维粥样硬化斑块与长期的不良心血管事件相关。冠状动脉不同部位发生易损斑块的概率不同。吸烟、高胆固醇血症与斑块不稳定性相关。他汀类药物可减少斑块容积,但是对斑块成分的影响仍不明确。目前仍无可靠的血清学标志物显示冠状动脉斑块的易损性。
The pathological mechanism behind the occurrence and development of coronary heart disease （CHD） is a topic that is con- sistently researched in efforts to reduce cardiac events. The methodology has focused on vulnerable lesions, plaques and patients. Intravascu- lar ultrasound virtual histology is one of the simplest and most effective means to study coronary artery lesion characteristics. The recent virtu- al histology intravaseular ultrasound study about acute coronary syndrome shows that thin-cap fihroatheroma plaques are associated with long- term adverse cardiovascular events. Vulnerable plaques, occur along different stages of coronary artery risk. Cigarette smoking and high cho- lesterol are both associated with plaque instability. Statins/medicines can reduce plaque volume, but the impact on the plaque composition is still uncertain. There are still no serological markers that show coronary artery plaque vulnerability.
出处
《心血管病学进展》
CAS
2015年第5期641-645,共5页
Advances in Cardiovascular Diseases
