摘要
目的：探讨对盐酸雷尼替丁胶囊的含量测定分析。方法：采用不同溶剂溶解盐酸雷尼替丁胶囊,采用高效液相色谱法测定盐酸雷尼替丁胶囊含量。结果：盐酸雷尼替丁在0.039 8～0.398 mg·m L-1范围内与峰面积积分值线性关系良好,平均回收率为99.70%,RSD=0.14%（n=6）。结论：盐酸雷尼替丁胶囊在流动相溶解下,含量更准确、重复性好,能更有效地控制盐酸雷尼替丁胶囊的含量测定。
Objective： To study the content determination of ranitidine hydrochloride capsule. Methods： The dissolution test was carried out with rotating-basket method. The results were analyzed and compared by the dissolution curves in different mediums. Results： The linear relationship of arctiin was in the range of 0. 0398 ～ 0. 398 mg·m L- 1. The average recovery rate was 99. 70%,RSD = 0. 14%（ n = 6）. Conclusion： The method is feasible with good reproducibility,which can control the content determination of Ranitidine Hydrochloride Capsule effectively.
出处
《赣南医学院学报》
2015年第4期526-528,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
盐酸雷尼替丁
含量测定
ranitidine hydrochloride capsule
content determination
