摘要
目的探讨加巴喷丁与曲马多联用缓解老年患者带状疱疹后遗神经疼痛的临床效果及安全性。方法选择我院2011年6月至2014年6月带状疱疹后遗神经疼痛老年患者170例,采用随机抽样方法分为对照组和试验组,每组85例;两组患者入院后均采用常规对症支持治疗;对照组患者采用盐酸曲马多单用口服治疗;试验组患者则采用盐酸曲马多与加巴喷丁联用口服治疗。比较两组患者疼痛缓解疗效,治疗前后视觉模拟评价量表评分(VAS)、匹兹堡睡眠质量评分(PSQI)及不良反应发生率等。结果对照组和试验组患者疼痛缓解显效率分别为30.59%、52.94%,临床治疗总有效率分别为63.53%、95.29%,两组比较差异有统计学意义(P<0.05)。治疗后两组VAS评分降低,且试验组低于对照组,差异有统计学意义(P<0.05);治疗后两组PSQI评分升高,且试验组高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论加巴喷丁与曲马多联用于老年带状疱疹后遗神经疼痛,可有效降低疼痛程度,提高睡眠质量,且不增加不良反应发生风险,疗效及安全性良好。
Objective To investigate the clinical effects and safety of gabapentin combined with tramadol in the treatment of elderly patients with post-herpetic neuralgia. Methods 170 elderly patients with post-herpetic neural-gia in our hospital were chosen from June 2011 to June 2014 in our hospital and randomly divided into 2 groups. Control group （ n=85 ） was given tramadol therapy orally, treatment group （ n =85 ） was given gabapentin combined with tramadol orally treatment on the basis of conventional systematic treatment. The pain relief efficacy, VAS,and PSQI before and after treatment and the incidence of adverse reaction of both groups were compared. Results The pain relief significant efficacy of control group and treatment group were 30.59% and 52. 94%;the total effec-tive rate of control group and treatment group were 63. 53% and 95. 29%, there were significant differences between the two groups （P〈0.05）. The VAS scores of both group decreased,and the score in treatment group was lower than that of control group （P〈0.05）. The PSQI scores of both group increased,and the score in treatment group was higher than that of control group （P〈0.05）. There was no significant difference in the incidence of adverse reaction between the two groups （P〉0.05）. Conclusion Gabapentin combined with tramadol in the treatment of elderly patients with post-herpetic neuralgia can efficiently reduce the pain degree,improve sleep quality with good clinical efficacy and safe-ty,and it do not increase the risk of adverse reactions.
出处
《实用药物与临床》
CAS
2015年第9期1045-1048,共4页
Practical Pharmacy and Clinical Remedies
