期刊文献+

光动力法联合复方倍他米松注射在增生性瘢痕治疗中的应用 被引量:12

Application of photodynamic therapy combined with compound betamethasone in treatment of hypertrophic scar
原文传递
导出
摘要 目的探讨光动力法联合复方倍他米松注射治疗增生性瘢痕的效果。方法37例患者随机分成2组,治疗组19例,对照组18例。治疗组采用光动力法联合复方倍他米松注射治疗,对照组单纯采用复方倍他米松局部注射治疗,比较治疗前、后的效果及复发率。结果治疗组有效率为89.5%,对照组55.6%,2组比较差异有统计学意义(P=0.029);治疗组复发率5.9%,对照组40.0%,2组比较差异有统计学意义(P=0.047)。结论光动力法联合复方倍他米松注射治疗增生性瘢痕效果明显,能减少激素使用的时间及不良反应,安全性高,值得临床推广。 Objective To investigate the effect of photodynamic therapy combined with compound betamethasone in the treatment of hypertrophic scar. Methods 37 cases of keloid were divided into two groups, 19 cases in the treatment group, 18 cases in the control group. The patients in treatment group were treated with photodynamic therapy combined with compound betamethasone injection therapy. The patients in the control group were treated by compound betamethasone injection. The effect and recurrence rate were compared before and after treatment. Results The effective rate was 89.5% in the treatment group, 55.6% in the control group, showing significant difference between the two groups ( P = 0. 029 ). The relapse rate in treatment group was significantly lower than that in the control group (P = 0. 047).Conclusions Photodynamic therapy combined with compound betamethasone has good effect and safety for the treatment of hypertrophic scar. The combined treatment can reduce the treatment period and side effects of hormone use.
出处 《中华整形外科杂志》 CAS CSCD 北大核心 2015年第5期343-346,共4页 Chinese Journal of Plastic Surgery
基金 福建省卫生厅青年基金(2013-2-45)
关键词 光动力 复方倍他米松 增生性瘢痕 Photodynamic therapy Compound betamethasone Hypertrophic scar
  • 相关文献

参考文献13

二级参考文献41

  • 1李伟,辛殿祺,郭应禄.前列腺癌PC-3细胞中Wnt信号通路与TGF-β信号通路相互调节[J].中华泌尿外科杂志,2006,27(S1):59-62. 被引量:6
  • 2Juarranz A, Jaen P, Sanz-Rodriguez F, et al. Photodynamictherapy of cancer. Basic principles and applications. Clin TranslOncol, 2008, 10(3): 148-154.
  • 3Batchelor R, Lamb S, Goulden V, et al. Photodynamic therapyfor the treatment of morphoea. Clin Exp Dermatol, 2008, 33 (5):661-663.
  • 4Orringer JS, Hammerberg C, Hamilton T, et al. Molecular effectsof photodynamic therapy for photoaging. Arch Dermatol, 2008,144( 10): 1296-1302.
  • 5Chiu LL, Sun CH, Yeh AT, et al. Photodynamic therapy onkeloid fibroblasts in tissue-engineered keratinocyte-fibroblastco-culture. Lasers Surg Med, 2005, 37(3 ): 231-244.
  • 6Colgrave ML, Allingham PG, Jones A. Hydroxyproline quanti-fication for the estimation of collagen in tissue using multiplereaction monitoring mass spectrometry. J Chromatogr A, 2008,1212(1-2): 150-153.
  • 7Clark IM, Swingler TE, Sampieri CL, et al. The regulation ofmatrix metalloproteinases and their inhibitors. Int J Biochem CellBiol, 2008, 40(6-7): 1362-1378.
  • 8Karrer S, Bosserhoff AK, Weiderer P, et al. Keratinocyte-derivedcytokines after photodynamic therapy and their paracrineinduction of matrix metalloproteinases in fibroblasts. Br JDermatol, 2004, 151(4): 776-783.
  • 9Niessen FB,Spauwen PH,Schalkwijk J,et al. On the nature of hypertrophic scars and keloids:a review [J]. Plast Reconstr Surg, 1999,104(5) : 1435-1458.
  • 10Niessen FB, Andriessen MP, Schalkwijk J, et al.Keratinocyt-derived growth factors play a role in the formation of hypertrophic scars [ J ]. J Pathol, 2001,194(2 ) : 207-216.

共引文献24

同被引文献109

引证文献12

二级引证文献90

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部