摘要
目的：提高对耐多药肺结核（multidrug －resistant tuberculosis，MDR －TB）患者治疗转归的认识。方法回顾性分析徐州市2009年—2012年纳入“全球基金结核病控制项目”治疗的128例MDR －TB患者的转归情况。结果128例MDR －TB患者中，治愈78例，治愈率为60．94％，不良反应失败10例，其他失败22例，死亡13例，丢失3例，其他（迁出患者，治疗结果未知）2例；统计分析不同肺部病变 MDR －TB 患者的治愈率，病变累及部分肺野患者的治愈率明显高于累及全肺野患者（χ^2＝6．767，P ＜0．05）；6个月末痰检阴性患者的治愈率高于阳性患者（χ^2＝6．677，P ＜0．05）；采用标准化方案与个体化方案的患者治愈率分别为47．69％、74．60％，两者差异有统计学意义（χ^2＝4．309，P ＜0．05）。结论MDR －TB 患者在“全球基金结核病控制项目”的管理、治疗下，获得效果较好。病变累及部分肺野、6个月末痰检阴性、采用个体化治疗方案的 MDR －TB 患者疗效更好。
Objective To improve the understanding of outcomes of multidrug resistant tuberculosis （MDR -TB）. Methods The outcomes were collected from 128 MDR -TB patients who were treated and managed according to ＂the Implementing Rules for Global Fund TB Project＂from 1 January 2009 to 31 December 2012 in Xuzhou before retrospec-tive analysis.Results Among all MDR -TB participants were 78 cured patients （60.94%）, while 10 cases of failure were reported due to adverse reactions, and 22 cases of failure due to other reasons, in addition to 13 cases of death, 3 discontinued cases and 2 other cases （transfer and unknown outcome）.Compared with MDR -TB patients with full in-jured lungs, a higher cure rate was measured among those whose lungs were partially injured （χ^2 =6.767, P 〈0.05）. Meanwhile, negative sputum culture participants produced a cure rate at the end of month 6 which was higher than posi-tive patients （χ^2 =6.677, P 〈0.05）.The cure rate was 47.69% for patients receiving the standardized treatment regi-men, which was statistically different from that of those given individualized regimens （74.60%） （χ^2 =4.309, P 〈0.05）.Conclusion The outcomes of MDR -TB patients included into the Project are satisfactory.Participants who re-port better efficacy are those with partial lung lesions, negative sputum at the end of month 6, and treated with individual-ized regimens.
出处
《徐州医学院学报》
CAS
2015年第8期534-536,共3页
Acta Academiae Medicinae Xuzhou
基金
全球基金结核病控制项目（CHN-506-G08-T）
关键词
结核
耐多药
治疗
转归
tuberculosis
multi - drug resistance
treatment
outcome
