血清神经元特异性烯醇化酶检测在缺血性脑卒中临床分型中的应用被引量：6

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摘要目的分析缺血性脑卒中患者血清神经元特异性烯醇化酶(NSE)水平,为缺血性脑卒中临床分型提供客观依据。方法收集缺血性脑卒中患者615例作为研究对象,依据牛津郡社区卒中计划(OCSP)将其分为完全前循环梗死(TACI)、部分前循环梗死(PACI)、后循环梗死(POCI)和腔隙性梗死(LACI)。以我院230例健康体检人群为对照组。采用酶联免疫分析法检测各型缺血性脑卒中患者及对照组的NSE含量,比较各型患者与对照组的NSE含量差异,并分析其与神经功能缺损评估(NIHSS)的相关性。结果 TACI组、PACI组、POCI组与LACI组的NSE含量分别为(32.7±5.0)μg/L、(26.3±5.5)μg/L、(18.9±4.4)μg/L和(12.6±3.9)μg/L,分别与对照组的(6.7±2.8)μg/L比较差异均有显著统计学意义(P<0.01),各型间NSE含量比较差异也有统计学意义(P<0.05),且与NIHSS评分呈正相关(P<0.05)。结论血清NSE检测可为临床上缺血性脑卒中患者进行准确的OCSP分型提供客观血清学指标,其与神经缺损程度呈正相关。

作者邓洁王定佑杨江勇

机构地区韶关学院医学院附属医院内科

出处《海南医学》 CAS 2015年第17期2583-2584,共2页 Hainan Medical Journal

基金韶关市科技计划项目(编号:2014CX/K259)

关键词缺血性脑卒中神经元特异性烯醇化酶 OCSP分型 NIHSS评分

分类号 R743.3 [医药卫生—神经病学与精神病学]

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