摘要
目的观察乌司他丁联合机械通气治疗儿童急性呼吸窘迫综合征(ARDS)的临床疗效。方法回顾性分析2011年1月至2014年6月本院儿科重症监护病房(PICU)收治的56例ARDS患儿的临床资料,在机械通气基础上,按是否使用乌司他丁分对照组(n=30)和治疗组(n=26),比较两组患儿治疗后的肺功能改善情况。结果两组患儿机械通气前的Pa O2/Fi O2值[(129.7±16.7)vs(128.5±18.8)]和Pa O2值[(46.7±6.8)vs(47.7±6.7)]比较差异均无统计学意义(P>0.05);两组患儿机械通气后24 h、48 h及72 h的Pa O2/Fi O2值、Fi O2值与治疗前比较均升高,差异均有统计学意义(P<0.05);治疗组患儿机械通气后24 h、48 h及72 h的Pa O2/Fi O2值、Fi O2值与对照组比较明显升高,差异均有统计学意义(P<0.05);治疗组热程、机械通气时间均较对照组缩短,差异均有统计学意义(P<0.05)。结论乌司他丁联合机械通气治疗小儿ARDS临床疗效显著。
Objective To observe the curative effect of ulinastatin combining mechanical ventilation for treating acute respiratory distress syndrome （ARDS） in children. Methods The clinical data of 56 children with AR-DS in Pediatric Intensive Care Unit （PICU） from January 2011 to June 2014 were retrospectively analyzed. The patients were divided into study group （n=26） and control group （n=30） according to whether they were treated by ulinastatin or not. Then clinical features and lung function after treatment were compared between the two groups. Results Before mechanical ventilation, the PaO2/FiO2 value [（129.7±16.7） vs （128.5±18.8）] and FiO2 value [（46.7±6.8） vs （47.7±6.7）] of two groups had no statistically significant difference （P〉0.05）. 24 h, 48 h and 72 h after mechanical ventilation, the PaO2/FiO2 value and FiO2 value of both groups were significantly increased, compared with those before treatment （P〈0.05）, and the two values of the study group were significantly higher those in the control group （P〈0.05）. The fever period and mechanical ventilation course of the study group were shortened than those in the control group, and the differences were statistically significant （P〈0.05）. Conclusion Ulinastatin combining mechanical ventilation has sig-nificant clinical effect for treating ARDS children.
出处
《海南医学》
CAS
2015年第18期2704-2706,共3页
Hainan Medical Journal
关键词
乌司他丁
急性呼吸窘迫综合征
儿童
疗效
Ulinastatin
Acute respiratory distress syndrome （ARDS）
Children
Clinical effect
