摘要
目的:观察开心散治疗血管性痴呆(VD)的临床疗效及对血清Livin的影响。方法:确诊的VD患者共200例,随机分为治疗组和对照组各100例,对照组给予安理申5 mg每晚临睡前口服,1个月为1个疗程。治疗组在对照组治疗的基础上同时给予中药"开心散"治疗,疗程同对照组。并通过简易智能精神量表(MMSE)来观察临床疗效,通过检测血管性痴呆(VD)患者血清抗凋亡因子(Livin)进行客观评价。结果:两组患者治疗后智能状况及血清Livin值均有所改善,且治疗组临床疗效优于对照组(P<0.05),血清Livin值的改善也优于对照组(P<0.05)。结论:开心散对VD患者有明显的治疗作用,对血清Livin也有正面的影响。
Objective: To observe the clinical effect of kaixin powder on cerebral vascular dementia(VD) and its effect on serum Livin. Methods: 200 cases of patients who had a confirmed diagnosis of VD were randomly di-vided into two groups, with 100 cases in each group. The control group was treated with donepezil hydrochloride tablets, 5 mg, per os hora somni, on this basis, the treatment group was given kaixin powder at the same time. 1 month was one course. The curative effect was evaluated by mini mental state evaluation( MMSE), and the serum Livin in patients was tested and compared. Results: After treatment, the mental state and serum Livin' s value of the two groups were all improved, the total effective rate of treatment group was 77.0%, higher than 66.0% of the control group ( P 〈 0.05 ), and the improvement of serum Livin' s value in treatment group was also superior to the control group( P 〈 0.05 ). Conclusion: Kaixin powder has obviously curative effect on VD patients, it also can improve the serum Livin.
出处
《山西中医》
2015年第8期14-16,共3页
Shanxi Journal of Traditional Chinese Medicine
基金
江苏省中医药局科技项目支助课题(编号:LZ13191)