摘要
目的探讨血清中磷脂酰肌醇蛋白聚糖-3(GPC3)、转化生长因子-β1(TGF-β1)2种肿瘤标志物在甲胎蛋白(AFP)阴性原发性肝癌(PHC)中的诊断价值及联合检测的意义。方法 PHC组90例,肝硬化组30例,良性肝病组30例,对照组健康体检者30例,检测血清中AFP、GPC3、TGF-β1的浓度,并进行比较。结果 PHC组患者血清AFP、GPC3、TGF-β1水平及阳性率均明显高于肝硬化组、良性肝病组及对照组,差异有统计学意义(P<0.05)。AFP阴性PHC患者血清AFP、GPC3、TGF-β1水平与AFP阳性PHC患者比较差异均无统计学意义(P>0.05)。AFP阴性PHC患者血清GPC3、TGF-β1水平及阳性率均明显高于肝硬化组、良性肝病组及对照组,差异有统计学意义(P<0.05)。GPC3与TGF-β1联合检测对AFP阴性PHC诊断的灵敏度及准确度明显高于单独检测。结论 GPC3与TGF-β1联合检测对PHC的诊断具有重要价值。
Objective To explore diagnosis value of the joint test of serumcan-3 （GPC3） and transforming growth factor-β1（TGF-β1） in alpha fetoprotein（AFP） negative primary hepatic carcinoma（PHC）patients. Methods A total of 90 PHC patients in PHC group, 30 patients in liver cirrhosis group, 30 patients in benign liver disease group, 30 people accepted physical examination in control group. The serum AFP,GPC3 and TGF -β1 in all the objects were detected and analyzed. Results The levels and positive rates of serum AFP,GPC3 and TGF-β1 in PHC group were significant higher than those of liver cirrhosis group, benign liver dis ease group and control group （P〈0.05）. The levels of serum C-PC3 and TGF-β1 in AFP negative PHC patients had no statistical significant with the AFP positive PHC patients （P〉0.05）. The levels and positive rates of serum GPC3 and TGF-β1 in AFP nega- tive PHC patients were significant higher than those of benign liver disease group and control, group （P〈0.05）. The sensitivity and diagnosis accuracy of the united detection of GPC3 and TGF-β1 were higher than single detection. Conclusion United detection of the serum GPC3 and TGF-β1 has important value to the diagnosis of AFP negative PHC.
出处
《国际检验医学杂志》
CAS
2015年第19期2787-2788,共2页
International Journal of Laboratory Medicine
基金
河北省卫生厅科研基金项目(20130540)
