期刊文献+

胆囊癌中趋化因子CXCL12和CXCR4的表达 被引量:2

The expression of chemokine CXCL12 and CXCR4 in gallbladder cancer
下载PDF
导出
摘要 目的研究原发性胆囊癌中趋化因子CXCL12和CXCR4的表达并讨论其临床其意义。方法选择2010-01~2014-12手术切除病理证实胆囊癌标本132例,其中男性74例,女性58例,选择24例正常胆囊作为对照。用免疫组织化学方法测定在胆囊癌和正常胆囊中CXCL12和CXCR4的表达。结果 CXCL12和CXCR4表达阳性染色均定位于胆囊癌细胞胞质。CXCL12和CXCR4表达在胆囊癌中的阳性表达率分别为69.7%(92/132)和62.1%(82/132),而正常胆囊表达分别为16.7%(4/24)和8.3%(2/24),胆囊癌中两者表达明显高于正常胆囊(P均〈0.01)。CXCL12和CXCR4表达与Nevin分期、淋巴结转移密切相关(P〈0.05)。结论 CXCL12和CXCR4在胆囊癌中有明显表达,且与Nevin分期、淋巴结转移密切相关,提示测定它们的表达对原发性胆囊癌的诊断具有一定临床意义。 Objective To investigate the expression of CXCL12 and CXCR4 in gallbladder cancer, and to explore its clinical signifi- cance. Methods From January 2010 to December 2014,132 cases of surgically confirmed gallbladder cancer were selected, 74 males and 58 females, and 24 cases of normal gallbladder were taken as controls. Expression of CXCL12 and CXCR4 was determined by im- munohistochemistry in gallbladder cancer and normal gallbladder. Results The positive CXCL12 and CXCR4 cells were expressed in gallbladder cancer cytoplasm. The positive rates of CXCL12 and CXCR4 expression were 69.7% (92/132) and 62.1% (82/132) in gallbladder cancer, and 16.7% (4/24) and 8.3 % (2/24) in normal gallbladder, respectively, and the expression in gallbladder canc- er was significantly higher than that in normal gallbladder(P 〈 0.01 ). The expression of CXCL12 and CXCR4 was closely related with Nevin stage and lymph node metastasis(P 〈 O. 05). Conclusion The results suggest that the CXCLI2 and CXCR4 expression may have some clinical significance for the diagnosis of primary gallbladder cancer.
出处 《山西医科大学学报》 CAS 2015年第9期885-888,共4页 Journal of Shanxi Medical University
基金 国家自然科学基金资助项目(30872965 30971337)
关键词 CXCL12 CXCR4 基因表达 免疫组织化学 胆囊癌 CXCL12 CXCR4 gene expression immunohistochemistry gallbladder cancer
  • 相关文献

参考文献6

二级参考文献49

  • 1王铮,徐勤鸿,李徐奇,沙焕臣,刘晗,马清涌.CXCL12/CXCR4轴在胰腺癌-神经交互作用中的研究[J].西安交通大学学报(医学版),2012,33(2):214-219. 被引量:3
  • 2秦净,王炳生,刘景磊,韩天权,张柏和,沈铭昌,邓杰,Asif Rashid,Ann W Hsing,高玉堂.手术对Ⅳ期胆囊癌预后的影响[J].肿瘤,2005,25(6):593-595. 被引量:4
  • 3石景森.胆囊癌确定治疗的思维程序[J].中华肝胆外科杂志,2006,12(3):157-158. 被引量:18
  • 4侯纯升,徐智,张同琳,彭颖,凌晓锋,王立新,周孝思.浸润深度局限在胆囊壁内的T1和T2期胆囊癌的预后分析[J].中华外科杂志,2006,44(23):1620-1623. 被引量:5
  • 5Fang Y,Wagman L,Gonen M,et al.Evidence-based gallbladder cancer staging changing cancer staging by analysis of data from the national cancer database.Ann Surg,2006,243:767-774.
  • 6Shimada H,Endo I,Togo S,et al.The role of lymph node dissection in the treatment of gallbladder carcinoma.Cancer,1997,79:892-899.
  • 7Chijiiwa K,Nakano K,Ueda I,et al.Surgical treatment of patients with T2 gallbladder carcinoma invading the subserosal layer.J Am Coll Surg,2001,192:600-607.
  • 8Sasaki R,Uesugi N,Itabashi H,et al.Clinicopathological study of depth of subserosal invasion in patients with pT2 gallbladder carcinoma.J Surg Oncol,2005,92:83-88.
  • 9Kakinuma T.Hwang ST.Chemokines,chemokine receptors,and cancer metastasis[J].Leukoc Biol,2006,79(4):639-651.
  • 10Balkwill F.Cancer and the chemokine network[J].Nat Rev Cancer,2004,4(7):540-550.

共引文献45

同被引文献24

引证文献2

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部