摘要
尼古丁的功效及作用机制是国内外研究的热点之一。医学领域一直将尼古丁作为烟草中的主要毒性物质,尼古丁可以改变神经递质系统的功能、调控细胞凋亡、调节细胞黏附分子表达、促进动脉粥样硬化、促进癌症的发生发展和抗生育效应等,对中枢神经系统、循环系统、呼吸系统、免疫系统、内分泌系统、生殖系统等都有一定的负性作用。本文主要对尼古丁的负性功效及作用机制研究进行综述。
The efficacy and mechanism of nicotine is one of the hot researches at home and abroad . Nicotine was considered as the main toxic substances of tobacco in medical domain all the time .It can change the function of neurotransmitter system ,regulate cell apoptosis ,regulate the expression of adhesion molecules , promote atherosclerosis ,promote the initiation and progression of cancer ,antifertility effect ,etc.It has negative effects on central nervous system , circulatory system,respiratory system, immune system, endocrine system and reproductive system , etc.This article reviewed the negative effects and mechanism of nicotine .
出处
《中华脑科疾病与康复杂志（电子版）》
2015年第4期69-73,共5页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
基金
山东省自然科学基金资助项目(ZR2011h1008
ZR2012AM021)
山东省卫生厅课题(2011HD017)
