摘要
目的:探讨宫血宁胶囊联合米非司酮对围绝经期功能失调性子宫出血患者血清性激素的影响。方法:92例围绝经期功能失调性子宫出血患者,随机分为两组,各46例。对照组给予炔诺酮治疗,观察组给予宫血宁胶囊联合米非司酮治疗。结果:观察组总有效率为95.65%高于对照组总有效率76.09%,差异具有统计学意义(P<0.01)。观察组复发率为2.17%少于对照组的复发率17.39%,差异具有统计学意义(P<0.05)。治疗后,观察组患者的FSH(22.05±5.31)U/L、LH(21.46±3.35)U/L、E2(118.27±30.42)pmol/L都低于对照组患者FSH(54.84±7.89)U/L、LH(38.53±6.68)U/L、E2(332.48±72.94)pmol/L,差异具有统计学意义(P<0.01)。治疗后,观察组患者HGB水平(107.54±10.21)g/L高于对照组患者HGB水平(96.42±10.46)g/L,差异具有统计学意义(P<0.01)。治疗后,观察组患者子宫内膜厚度(4.26±0.84)mm低于对照组患者子宫内膜厚度(5.52±1.13)mm,差异具有统计学意义(P<0.01)。观察组患者控制出血时间(21.63±6.89)h、完全止血时间(56.92±14.17)h都少于对照组患者控制出血时间(32.18±7.72)h、完全止血时间(67.48±23.67)h,差异具有统计学意义(P<0.05)。结论:宫血宁胶囊联合米非司酮治疗围绝经期功能失调性子宫出血疗效显著,能改善患者血清性激素水平,及时有效控制出血,改善子宫内膜厚度。
Objectives：To investigate the effect of Gongxuening capsule combined with mifepristone inter-vention on the serum sex hormone levels of patients with perimenopausal dysfunctional uterine bleeding.Methods：92 patients with perimenopausal dysfunctional uterine bleeding,were randomly divided into two groups,46 cases in each.Control group was given norethisterone treatment while observation group was given Gongxuening capsule com-bined with mifepristone.Results：The total efficiency of the observation group was 95.65%,higher than that of the control group of 76.09%,with statistically significant differences （P 〈0.01）.The recurrence rate was 2.17% in the observation group,smaller than that in the control group of 17.39%,with statistically significant difference （P 〈0.05）.After treatment,FSH （22.05 ±5.31）U /L,LH （21.46 ±3.35）U /L,E2 （118.27 ±30.42）pmol/L in the observation group were lower than those in the control group which were FSH （54.84 ±7.89）U /L,LH （38.53 ±6.68）U /L,E2 （332.48 ±72.94）pmol/L respectively,with statistically significant difference （P 〈0.01）.After treatment,the level of HGB （107.54 ±10.21）g/L in the observation group was higher than that in the control group of （96.42 ±10.46）g/L,with statistically significant difference （P 〈0.01）.After treatment,the thickness of endometrium （4.26 ±0.84）mm in the observation group was lower than that in the control group of （5.52 ±1.13）mm,with statistically significant difference （P 〈0.01）.The bleeding control time （21.63 ±6.89） h and hemostasis time （56.92 ±14.17）h in the observation group were less than those in the control group which were （32.18 ±7.72）h and （67.48 ±23.67）h respectively,with statistically significant difference （P 〈0.05）. Conclusions：Gongxuening capsule combined with mifepristone is of good curative effect in the treatment of perim-enopausal dysfunctional uterine bleeding,which can improve the serum sex hormone levels of patients timely,re-duce bleeding of patients and improve the endometrial thickness.
出处
《中国性科学》
2015年第9期25-28,共4页
Chinese Journal of Human Sexuality
关键词
围绝经期
功能失调性子宫出血
宫血宁胶囊
米非司酮
性激素
Perimenopausal period
Dysfunctional uterine bleeding
Gongxuening capsule
Mife-pristone
Sex hormone
