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托烷司琼和地塞米松联合奥氮平预防肺癌患者化疗所致恶心、呕吐的疗效观察 被引量:5

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摘要 目的观察托烷司琼和地塞米松联合奥氮平预防肺癌患者化疗所致恶心、呕吐(CINV)的疗效。方法 86例肺癌患者随机分为观察组和对照组,各43例。观察组化疗前静脉滴注托烷司琼5 mg,地塞米松10 mg入壶,口服奥氮平10 mg;对照组化疗前静脉滴注托烷司琼5 mg,地塞米松10 mg入壶,不口服奥氮平。上述两组药物均应用5 d,化疗1个周期后评价止吐效果。结果观察组急性CINV发生率为18.6%,对照组急性CINV发生率为20.1%,两组比较差异无统计学意义(P>0.05);观察组延迟性CINV发生率为25.6%,对照组延迟性CINV发生率为65.1%,两组比较差异具有统计学意义(P<0.05)。结论托烷司琼和地塞米松联合奥氮平预防肺癌患者化疗所致延迟性CINV的疗效好于托烷司琼和地塞米松两药联合,值得推广应用。
作者 陈立杰
出处 《中国现代药物应用》 2015年第19期140-142,共3页 Chinese Journal of Modern Drug Application
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