摘要
目的了解广东省2010-2013年健康人群C群脑膜炎奈瑟菌（Neisseria meningitidis,Nm）抗体水平及变化趋势,为预防控制流行性脑脊髓膜炎（流脑）提供参考。方法按照《全国流脑监测点工作手册（2010年）》要求,并结合广东省实际情况,连续在广州、东莞和韶关市采集健康人群血标本,采用杀菌力试验方法,测定血清中C群Nm抗体。结果 2010-2013年,共采集健康人群血标本3158份。C群Nm抗体阳性率和保护率,分别从2010年的29.83%和27.36%上升到2013年的45.94%和41.61%。健康人群C群Nm抗体阳性率和保护率出生后逐渐降低,3岁前降到最低水平,3岁后明显上升,5-14岁有所降低,15岁以后又缓慢上升。健康人群C群Nm抗体阳性率和保护率从高到低依次为广州、东莞和韶关市。男性的C群Nm抗体阳性率和保护率均高于女性。结论广东省2008年9月将A＋C群脑膜炎球菌多糖疫苗纳入国家免疫规划,2010-2013年健康人群C群Nm抗体水平逐年提高,但仍存在年龄、地区和性别差异。
Objective To ascertain antibody levels against Serogroup C Neisseria meningitidis in a healthy population of Guangdong province from 2010 to 2013,and to provide a scientific basis for the prevention of meningococcal disease. Methods In accordance with the ＂ National Surveillance Sites of Manual Work of Meningococcal Disease（ 2010）,＂ and combined with the real-world situation in Guangdong province,blood samples were continuously collected from a healthy population in Guangzhou,Dongguan and Shaoguan. Serum Bactericidal Assays（ SAB） were used to assess antibody levels against Serogroup C Neisseria meningitidis. Results A total of 3158 serum samples were collected from a healthy population between 2010 and 2013. The antibody positivity rate and protective rate against Serogroup C Neisseria meningitidis increased year by year,up to45. 94% and 41. 61% in 2013 from 29. 83% and 27. 36% in 2010,respectively. The serogroup C antibody positivity rate and the protective rate gradually decreased after birth,dropping to its lowest level by 3 years of age,but increasing significantly at 3 years of age,decreasing again between 5- 14 years old,and finally increasing slowly after the age of 15 years. Healthy population Serogroup C antibody positive rates and protective rates ranked from high to low in the order of Guangzhou,Dongguan,and Shaoguan. Serogroup C antibody positive rates and protective rates were higher among males than among females. Conclusion Guangdong Province introduced AC meningococcal polysaccharide vaccine into national immunization programs in September 2008. The antibody positive rate and protection rate against Serogroup C Neisseria meningitidis increased year by year,but varies by age,region,and gender.
出处
《中国疫苗和免疫》
CAS
北大核心
2015年第2期177-180,215,共5页
Chinese Journal of Vaccines and Immunization
