摘要
目的研究尿路感染患者病原菌分布及耐药性,为临床医师合理用药提供实验室依据。方法对2013年1-12月医院门诊和住院的300例尿路感染患者清晨中段尿进行细菌培养,菌株鉴定与药敏试验采用法国生物梅里埃公司VITEK-2Compact全自动细菌鉴定仪、配套鉴定卡和药敏卡,研究数据采用WHONET5.6软件进行统计分析。结果 300例尿路感染患者送检尿液标本检出病原菌210株,检出率为70.0%;其中革兰阴性菌137株占65.2%、革兰阳性菌53株占25.2%、真菌20株占9.6%;大肠埃希菌对哌拉西林耐药率最高为80.2%,肺炎克雷伯菌对哌拉西林、氨苄西林的耐药率均为100.0%,屎肠球菌对莫西沙星、环丙沙星、左氧氟沙星、氨苄西林、克林霉素和红霉素的耐药率均为100.0%,粪肠球菌对庆大霉素、克林霉素及红霉素的耐药率均为100.0%。结论尿路感染不同病原菌耐药性差异较大,临床医师应尽快送检尿液培养,根据药敏结果合理使用抗菌药物,经验性用药可选择哌拉西林/他唑巴坦。
OBJECTIVE To study the composition ratio and drug resistance of urinary tract infection pathogens so as to provide laboratory evidence for clinical rational drug use .METHODS During Jan .2013 to Dec .2013 ,totally 300 cases of urine samples from urinary tract infection patients in the early morning were cultured ,and the bacteria i‐dentification and drug sensitivity tests were performed by VITEK‐2 COMPACT instrument .RESULTS A total of 210 strains of pathogenic bacteria were isolated from the 300 urine samples and the detection rate was 70 .0% . Pathogens were gram‐negative bacteria mainly with 137 strains ,accounting for 65 .2% .Gram‐positive bacteria had 53 strains and accounted for 25 .2% .Fungi with 20 strains accounted for 9 .6% .Escherichia coli were highly re‐sistant to piperacillin with the resistance rate of 80 .2% ;K lebsiella pneumoniae were 100 .0% resistant to pip‐eracillin and ampicillin .Enterococcus f aecium were highly resistant to moxifloxacin ,ciprofloxacin ,levofloxacin , ampicillin ,clindamycin ,and erythromycinwith the rate of 100 .0% ;Enterococcus f aecalis were 100 .0% resistant to gentamicin ,clindamycin and erythrocin .CONCLUSION The antibiotic resistance of different pathogens of urina‐ry tract infection varies greatly .The clinicians should perform urine culture as soon as possible and use antibiotics rationally basing on the antimicrobial susceptibility results .Piperacillin/tazobactam can be used as empiric drug .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第19期4396-4397,4403,共3页
Chinese Journal of Nosocomiology
基金
陕西省科技攻关基金资助项目(2012K06-31)
关键词
尿路感染
患者
病原菌
耐药性
U rinary tract infection
Patients
Pathogens
Drug resistance
