摘要
目的研究肺结核患者血小板参数、D-二聚体及纤维蛋白原(Fg)水平的变化及其临床意义。方法测定100例肺结核患者(其中活动性肺结核、非活动性肺结核患者各50例)及50例健康体检者(对照组)的血小板参数、D-二聚体及纤维蛋白原水平,并进行比较。结果活动性肺结核组、非活动组与对照组比较,D-二聚体及纤维蛋白原(Fg)、血小板计数(PLT)、平均血小板容积(MPV)水平显著增加,差异有统计学意义(P<0.05),且活动性肺结核组较非活动组升高更为明显,差异有统计学意义(P<0.05);而血小板分布宽度(PDW)及大血小板比率(P-LCR)3组间无明显变化。D-二聚体及Fg、PLT、MPV水平在抗结核治疗后呈显著下降,差异有统计学意义(P<0.05)。结论肺结核患者体内存在高凝状态,监测上述指标,对预防血栓性并发症有重要临床意义。
Objective To investigate the clinical significance of the changes in platelet parameters, D - dimmer and fibrinogen level of patients with tuberculosis. Methods Testing the platelet parameters and the levels of the D - dimmer and fibrinogen of 100 tuberculosis patients （ active tuberculosis patients 50 cases and non active tuberculosis patients 50 cases） and 50 healthy ordinary people （the control group）, and taking comparison as well. Results Comparing the active -tuberculosis group with the control group and non - active - tuberculosis group, the D - dimer and fibrinogen（ Fg）, the platelet count（PLT） and the av- erage ptatelet volume（MPV） had remarkably increased, and the difference had statistical significance （P 〈 0.05 ）, and com- pared to the non - active - tuberculosis group, the increase of the active - tuberculosis group was more evident （P 〈 0.05 ）. Moreover, the platelet distribution width （PDW） and the large platelet ratio had no significant difference among the three groups. The levels of the D -dimer and fibrinogen（ Fg）, the Platelet count（PLT） and the average platelet volume（MPV） sig- nificantly declined after the anti tuberculosis treatment in patients （P 〈 0.05）. Conclusion The presence of high coagulation state happened on patients with pulmonary tuberculosis, so monitoring these indicators has important clinical significance in the prevention of thrombotic complications.
出处
《中国卫生检验杂志》
CAS
2015年第18期3127-3129,3132,共4页
Chinese Journal of Health Laboratory Technology
