摘要
目的探讨2型糖尿病下肢血管病变(PAD)患者的踝肱指数(ABI)与尿白蛋白、可溶性细胞间黏附分子-1(sICAM-1)的关系。方法分析342例2型糖尿病患者测得的ABI、24 h尿白蛋白(24 h-μAlb)、空腹血糖(FBG)、餐后2 h血糖(2 h BG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、sICAM-1水平,其中ABI≤0.9患者为下肢血管病变(PAD)组,48例,占14.8%;0.9<ABI<1.3的为非PAD组,294例。两组患者的ABI病程、年龄、24 h-μAlb、FBG、2h BG、TG、HDL-C、LDL-C水平采用x±s表示,组间比较采用t检验,ABI与各指标的相关分析采用多元线性回归分析。结果 PAD组尿白蛋白[(125.4±108.2)mg,(67.6±55.5)mg,t=5.47,P<0.05]和s ICAM-1[(278.6±234.1)ng/ml,(161.5±115.2)ng/ml,t=5.01,P<0.05]、年龄[(67.7±15.4)岁,(54.2±12.8)岁,t=3.08,P<0.05]、病程[(15.4±14.1)年,(8.2±7.5)年,t=4.06,P<0.05]、LDL-C[(1.8±1.7)mmol/L,(1.0±1.1)mmol/L,t=6.85,P<0.05]、2 h BG[(15.8±5.2)mmol/L,(11.0±4.4)mmol/L,t=2.96,P<0.05]水平均高于非PAD组,差异有统计学意义;ABI值[(0.8±0.2),(1.2±0.2)]水平则低于非PAD组,差异有统计学意义(t=3.53,P<0.05)。PAD患者ABI与24 h-μA1b(r=-0.207,P<0.05)、sICAM-1水平呈负相关(r=-0.201,P<0.05)。结论 ABI可作为筛查2型糖尿病患者下肢血管病变与糖尿病肾病的方法,并反映其炎症指标。
Objective To study the relationship of ankle?brachial index ( ABI ) and the urinary albumin,soluble intercellular adhesion molecule?1(sICAM?1) in patients with type 2 diabetic peripheral arterial disease ( PAD) . Methods Three hundred and forty?two patients with T2DM were divided into two groups according to the results of ABI,forty?eight cases in PAD group(ABI≤0.9) and two hundred and ninty four cases in non?PAD group(0.9<ABI≤1.3).At the same time,urinary albumin(μAlb),sICAM?1, triglyceride ( TG) ,total cholesterol ( TC) ,low density lipoprotein ( LDL) ,high density lipoprotein ( HDL) , fasting blood glucose (FBG),2?hour postprandial blood glucose (2hBG) of all patients were tested.The value of the two groups were compared by t?test, and the correlations were analyzed by liner?regression analysis.Results μAlb[(125.4±108.2)mg,(67.6±55.5)mg, t =5.47, P < 0.05 ],sICAM?1 [(278.6± 234.1)ng/ml,(161.5±115.2)ng/ml, t =5.01, P <0.05],the age[(67.7±15.4) years, (54.2±12.8) years, t =3.08, P<0.05],diabetic history[(15.4±14.1) years,(8.2±7.5) years, t =4.06, P <0.05], LDL?C[(1.8±1.7)mmol/L,(1.0±1.1)mmol/L, t =6.85, P <0.05],2hBG[(15.8±5.2)mmol/L, (11.0±4.4)mmol/L, t =2.96, P <0.05] in PAD group were higher than those in non?PAD group.ABI [(0.8±0.2),(1.2±0.2)] in PAD group was lower than that in non?PAD group ( t =3.53, P <0.05).Multiple linear regression showed that ABI was correlated with μAlb (r =-0.207, P<0.05) and sICAM?1 (r =- 0.201 , P<0.05).Conclusion ABI can be used as index for screening peripheral arterial disease and diabetic nephropathy in patients with type 2 diabetes,and reflect its inflammatory markers.
出处
《中华诊断学电子杂志》
2015年第3期40-42,共3页
Chinese Journal of Diagnostics(Electronic Edition)
基金
深圳市罗湖区软科学研究计划项目(2011037)
关键词
糖尿病
2型
踝肱指数
白蛋白尿
细胞间黏附分子-1
Diabetes mellitus
type 2
Ankle-brachial index
Albuminuria
Intercellular adhesion molecule-1
