摘要
目的:探讨PCT、CRP在感染性疾病诊断中的价值,评价两者与感染类型的相关性。方法:回顾性统计分析420例发热待查的患者血清PCT,血浆CRP浓度与感染的关系,采用胶体金法检测血清中PCT的浓度,免疫荧光比色法检测血浆中CRP浓度,血培养及血清学的方法检测感染是否存在及感染类型。结果:通过血培养或血清学鉴定出132例存在细菌感染(细菌组),病毒感染103例(病毒组),细菌病毒混合感染76例(混合感染组),109例阴性(非感染组)。PCT在细菌组水平最高(20.6±6.7)μg/L,非感染组水平最低(8.7±2.3)μg/L,四组间差异有统计学意义(F=34.69,P<0.05)。CRP在混合组中水平最高(18.1±3.7)mg/L,在非感染组水平最低(5.8±1.7)mg/L,四组间差异有统计学意义(F=23.55,P<0.05)。PCT对细菌感染检测的敏感度为92.7%,特异度为63.2%。PCT对病毒感染检测的敏感度为78.7%,特异性为46.0%。细菌感染组、病毒感染组和混合感染组血清CRP和PCT均呈正相关(P=0.00<0.05)。结论:细菌感染的PCT、CRP血清浓度明显高于病毒感染,两者对细菌感染患者的特异性均明显高于病毒感染,细菌感染PCT血清浓度较CRP变化敏感。
Objective： To explore the value of Procalcitonin （PCT） and C-reactive protein （CRP） in the diagnosis of infectious diseases, and to evaluate their relevance to the type of infection. Methods： A retrospective statistical analysis was performed including 420 cases of patients with fever, and the relationship between serum PCT and CRP levels was analyzed. The concentration of serum PCT was detected using colloidal gold method and CRP was detected using immunofluorescence colorimetry. Results： Within 420 cases of patients with fever, 132 cases were diagnosed with bacterial infection through blood cultures or serological detection （bacteria group）. 103 cases were diagnosed with virus infection （virus group）. 76 cases was detected with bacterial virus infection （mixed group）, and 109 cases was detected as negative （negative group）. The bacteria group had the highest PCT level （20.6 ± 6.7） μg/L, and the negative group had the lowest PCT level （8.7± 2.3） μg/L. The PCT level was statistically different between the four groups （F=34.69, P〈 0.05）. The CRP level in mixed group was the highest （18.1± 3.7） mg/L, and the lowest in negative group （5.8± 1.7） mg/L. It was also statistically different between the four groups （F=23.55, P〈 0.05）. The sensitivity of the PCT for bacterial infections was 92.7%, and specificity was 63.2%. As for detecting virus infection, the sensitivity of PCT was 78.7%, and specificity was 46.0%. CRP and PCT levels in bacterial infection, virus infection or mixed infection were positively correlated between them （p =0.00 〈 0.05）. Conclusion： The serum concentration of PCT and CRP in bacterial infection was obviously higher than that in virus infection. The specificity of PCT and CRP were both significantly higher in patients with bacterial infection than in those with virus infection. The serum concentrations of PCT in bacteria infection were more sensitive than the CRP.
出处
《现代生物医学进展》
CAS
2015年第22期4348-4350,共3页
Progress in Modern Biomedicine
基金
卫生部医药卫生科技发展研究中心课题基金(W2011GJ13)
