摘要
目的 分析肺部真菌感染（pulmonary fungal infection,PFI）行手术治疗患者的临床特征。方法 回顾性分析复旦大学附属中山医院胸外科2008年6月至2014年12月期间已行手术且病理证实的45例PFI患者的临床资料,包括其临床表现、影像学表现、病理特征、手术方式和预后。结果45例患者中男性23例（51.1%）,女性22例,年龄17~73岁,平均年龄51岁。体检发现的无症状患者为31例（68.9%）;影像学检查提示病灶为阴影、占位或空洞型病变,多考虑炎症可能,主要分布于双肺下叶;病理结果多数倾向于隐球菌或新型隐球菌感染;最终所有患者接受胸腔镜下肺叶或亚肺叶切除手术,多数辅以抗菌药物,疾病预后相对良好,随访未见复发。结论 PFI的临床表现无特异性,症状轻重不一,虽然是良性疾病,但有时和肺部肿瘤难以区分。药物治疗和手术治疗为PFI的主要治疗手段,手术治疗对于患者来说是安全有效的。
Objective To investigate the clinical features of pulmonary fungal infection （PFI）. Methods Clinical data including clinical manifestation, imaging findings, histopathological features, surgical treatment and prognosis of 45 cases with postoperative pathologically proven PFI in Zhongshan Hospital,Fudan University between Jun. 2008 and Dec. 2014 were analyzed retrospectively. Results Among the 45 cases,23 （51. 1%） were males,22 were females. The age of them ranged from 17 to 73 years,the average age was 51 years. Thirty-one（68. 9%） cases were found in routine physical examination and were free of symptoms. The lesions presented as shadow, space occupying mass or cavity mainly located in the lower lobes of the lung, and looked like inflammatory changes. Most lesions were pathological proven cryptococcus or neoformans. All patients underwent operation and had no severe complications. Most patients used anti-fungal drugs after operation. During the postoperative follow-up, there was no recurrence. Conclusions Although pulmonary fungal infection is benign, it is difficulty to be distinguished from lung tumor. Limited resection and lobectomy by VATS are good choice for untypical PFI.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2015年第5期639-641,683,共4页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金(81401875
81472225)
上海市自然科学基金(14ZR1406000)~~
关键词
肺内结节
肺部真菌感染
手术治疗
pulmonary nodule
pulmonary fungal infection
surgical treatment
