摘要
目的评价替吉奥联合顺铂对晚期胃癌治疗效果及毒副作用。方法选取2012年3月至2013年6月期间收治的80例晚期胃癌患者作为研究对象,随机分为治疗组和对照组,每组40例。治疗组患者给予替吉奥及顺铂联合治疗,对照组患者给予5-氟尿嘧啶及顺铂联合治疗。比较两组患者治疗效果及毒副作用情况。结果治疗组近期治疗有效率55.0%显著高于对照组的30.0%(P<0.05);治疗组患者接受治疗后KPS评分改善率为62.5%,明显高于对照组患者的40.0%,差异具有显著性(P<0.05);治疗组放射性肺炎、恶心呕吐、放射性食管炎发生率略低于对照组,但两组之间比较差异无显著性(P>0.05);对两组患者进行为期两年的随访,治疗组一年生存率为40.0%高于对照组患者的25.0%,但差异无显著性(P>0.05);治疗组患者两年生存率为30.0%,显著高于对照组患者的10.0%,差异具有显著性(P<0.05)。结论对于无法采取手术方法治疗的晚期胃癌者进行替吉奥联合顺铂治疗能显著提高治疗效果和患者生存率,且毒副作用未见有加重。
Objective To evaluate for gonow combined cisplatin for the treatment of advanced gastric cancer effect and side effects. Methods From March 2012 to June 2013,80 cases of patients with advanced gastric cancer were considered as the research object. All patients were randomly divided into treatment group and control group,40 cases in each group. The patients of treatment group were given gonow and cispl-atin combination therapy. The patients of control group were given 5 - Fu and cisplatin combination treatment. The therapeutic effect and side effects were compared between the two groups of patients. Results The treatment effective rate in treatment group patients was 55. 0% . The treat-ment effective rate of the control group was 30. 0% . The recent treatment efficiency of treatment group was significantly higher than the control group（ P ﹤ 0. 05）. Treatment group after treatment in patients with KPS score period was 62. 5% ,the control group after treatment in patients with KPS score was 40. 0% . The difference was statistically significant（ P ﹤ 0. 05）. Treatment group,nausea and vomiting,radioactive esoph-agitis incidence of radioactive pneumonia was slightly lower than the control group,but no significant difference compared between two groups（ P﹥ 0. 05）. On two groups of patients,the two - year follow - up control patients survival rate of 25. 0% one year,two years of survival rate is 10. 0% ,Treatment group survival rate of 40. 0% one year,two years survival rate was 30. 0% ,the treatment group patients two years of survival rate is significantly higher than control group（ P ﹤ 0. 05）. Conclusion Advanced gastric cancer who can＇t take a surgical approach for gonow treated with cisplatin can significantly improve the treatment effect and survival rate of the patients,and side effects of compound has not been observed.
出处
《临床和实验医学杂志》
2015年第19期1595-1597,共3页
Journal of Clinical and Experimental Medicine
关键词
晚期胃癌
替吉奥
顺铂
5-氟尿嘧啶
Advanced gastric cancer
On behalf of gonow
Cisplatin
5 - Fluorouracil
