摘要
目的研究血细胞比容及碱剩余评估特重烧伤患者休克复苏效果的临床价值。方法将2012年4月至2014年6月期间就诊的40例特重度烧伤伴休克患者纳入研究对象,入院后接受液体复苏治疗,根据复苏后1 d和2 d时血细胞比容以及碱剩余情况不同分为正常组和异常组。采用酶联免疫吸附法检测白细胞介素4(IL-4)和白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)。结果复苏后1 d和2 d时,血细胞比容正常组不同时点血比容均明显低于异常组,IL-4、IL-6、TNF-α含量均低于血细胞比容异常组;碱剩余正常组不同时点碱剩余含量均明显高于对照组,IL-4、IL-6、TNF-α含量均低于碱剩余异常组。结论血细胞比容越低、碱剩余越高,特重烧伤患者休克复苏后的炎症反应越弱、复苏效果越好;血细胞比容及碱剩余是评估复苏效果的理想指标。
Objective To study the clinical significance of hematocrit and alkaline excess in evaluating resuscitation effect of shock in pa-tients with severe burn. Methods A total of 40 patients with severe burn complicated with shock in this hospital during April 2012 to June 2014 were enrolled in this study and fluid had been given to them for resuscitation. These patients were divided into two groups according to hematocrit and alkaline excess at 1 d and 3 d after fluid resuscitation. Serum levels of interleukin - 4（IL - 4）,IL - 6 and tumor necrosis factor - α（TNF -α）were detected by enzyme - linked immunosorbent assay（ELISA）. Results After fluid restoration for 1d and 2 days,hematocrit in normal group at different time point was significantly lower than that of abnormal group,serum levels of IL - 4,IL - 6 and TNF - α were significantly low-er than those of abnormal group;alkaline excess in normal group at different time point was significantly higher than those of abnormal group,ser-um levels of IL - 4,IL - 6 and TNF - α were significantly lower than those of abnormal group. Conclusion As hematocrit gets lower and alkaline excess gets higher,the inflammatory reaction in patients with severe burn is weaker and resuscitation effect is better;hematocrit and alkaline excess are ideal indexes for evaluating resuscitation effect of shock in patients with severe burn.
出处
《临床和实验医学杂志》
2015年第19期1613-1616,共4页
Journal of Clinical and Experimental Medicine
关键词
烧伤
休克复苏
血细胞比容
碱剩余
炎症因子
Burn
Shock resuscitation
Hematocrit
Akaline excess
Inflammatory factor
