摘要
目的探讨肽基脯氨酰顺反异构酶1(PIN1)蛋白在胃癌组织中的表达及其临床意义。方法应用MaxEnvision免疫组化法检测213例胃癌组织及40例正常胃黏膜组织中PIN1蛋白表达,分析其与临床病理参数及患者术后生存率的关系。结果胃癌组织中PIN1蛋白阳性表达率高于正常胃黏膜组织(34.3%vs.17.5%)(P<0.05)。有淋巴结转移者(97例)的胃癌组织PIN1蛋白阳性表达率低于无淋巴结转移者(116例)(26.80%vs.40.52%)(P<0.05),PIN1蛋白阳性表达患者(73例)5年生存率低于阴性表达患者(140例)(17.8%vs.45.0%)(P<0.05)。结论胃癌组织PIN1蛋白表达可作为筛选高危淋巴结转移患者和预测胃癌预后的有用指标。
Objective To explore the expression and clinical significance of peptidyl-prolyl cis-trans isomerase 1（PIN1） protein in gastric carcinoma .Methods The expression of PIN1 protein was detected by MaxEnvision immunohistochemistry in gastric carcinoma（group A ,213 cases） and normal gastric mucosa（group B ,40 cases） .The relationship between PIN1 expression and clinicopathological parameters and postoperative survival rate was analyzed .Results The positive expression rate of PIN1 protein in group A was higher than that in group B（34.3% vs .17.5% ）（P〈0 .05） .The positive expression rate of PIN1 protein in group A was lower in the patients with lymph node metastasis （97 cases） than that in those without（116 cases）（26.80% vs .40.52% ）（P〈0 .05） .The five-year survival rate was lower in the patients with PIN1 positive expression（73 cases） than that in those with PIN1 negative expression（140 cases）（17.8% vs .45.0% ）（P〈0 .05） .Conclusion The expression of PIN1 protein in gastric carcinoma can be a useful indicator for screening high-risk patients with lymph node metastasis and predicting the prognosis of the patients with gastric carcinoma .
出处
《江苏医药》
CAS
2015年第18期2128-2130,共3页
Jiangsu Medical Journal
基金
江苏省教研室课题资助项目(J201203)
关键词
胃癌
肽基脯氨酰顺反异构酶1
Gastric carcinoma
Peptidyl-prolyl cis-trans isomerase 1
