摘要
[目的]评价子宫上皮细胞稳定性FH检测技术在诊断宫颈癌及癌前病变中的临床意义。[方法]对经病理学诊断的宫颈上皮内瘤变（CIN）、宫颈癌、宫颈良性病变及宫颈正常的女性共540例,进行子宫上皮细胞稳定性FH检测和宫颈细胞学（TCT）检查,比较两种检测方法的敏感度及特异性。[结果]子宫上皮细胞稳定性FH检测诊断CIN2-3、宫颈癌的敏感度分别为76.3%（95%CI：70.3%-82.2%）、94.4%（95%CI：89.1%-99.7%）,与TCT检测的敏感度差异无统计学意义。子宫上皮细胞稳定性FH检测诊断宫颈病变的特异性为64.4%（95%CI：58.7%-70.2%）,低于TCT检测的特异性。[结论 ]子宫上皮细胞稳定性FH检测对诊断宫颈病变具有较高的敏感度,且具有快速、简便、经济的特点,适用于偏远贫困地区女性的宫颈癌筛查。
[Purpose] To investigate the clinical significance of uterine epithelial cells stability FH test in cervical cancer and precancerous lesions. [Methods] A total of 540 women pathologically diagnosed with cervical intraepithelial neoplasia（CIN）,cervical cancer,cervical benign lesions and normal cervix were detected by uterine epithelial cells stability FH test and Thin-prep cytology test（TCT）. The sensitivity and specificity of Thin-prep cytology test（TCT） and uterine epithelial cells stability FH test for cervical lesions were compared. [Results] The sensitivity of uterine epithelial cells stability FH test in detecting CIN,cervical cancer were 76.3%（95% CI：70.3% -82.2%）,94.4%（95% CI：89.1% -99.7%）,respectively,which was no significant difference compared with TCT test. The specificity of uterine epithelial cells stability FH test in detecting cervical lesions was 64.4%（95%CI：58.7%-70.2%）,which was lower than that in TCT test. [Conclusion] Uterine epithelial cells stability FH test,characterized as is rapid,simple and economical,has a high sensitivity in detecting cervical lesions,and can be used for cervical cancer screening,especially for women in remote poverty-stricken areas.
出处
《中国肿瘤》
CAS
2015年第10期881-883,共3页
China Cancer
基金
山东省科技发展计划项目(2014GGH218029)
山东大学齐鲁医院科研基金资助项目(2015QLMS48)
关键词
子宫上皮细胞稳定性FH检测
宫颈癌
游离亚铁血红素
敏感度
特异性
uterine epithelial cells stability FH test
cervical cancer
cervical precancerous lesions
free heme
sensitivity
specificity
