摘要
目的探究氨氯地平阿托伐他汀钙治疗原发性高血压合并多重心血管疾病危险因素患者的临床疗效。方法选取2011年3月—2013年2月西安市第五医院心内科收治的原发性高血压合并多重心血管疾病危险因素患者144例,按照随机数字表法分为治疗组和对照组,每组72例。治疗组患者给予氨氯地平阿托伐他汀钙片治疗,对照组患者给予氨氯地平片治疗,两组患者均治疗48周。比较两组患者治疗前及治疗后4周、24周、48周血压,治疗前后血脂指标〔总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)〕及Framingham危险评分。结果两组患者治疗前及治疗后4周、24周、48周收缩压及舒张压比较,差异无统计学意义(P>0.05);两组患者治疗后4周、24周、48周收缩压及舒张压均低于治疗前(P<0.05)。两组患者治疗前血清TC、TG、HDL-C、LDL-C水平及Framingham危险评分比较,差异无统计学意义(P>0.05);治疗组患者治疗后血清TC、TG、LDL-C水平及Framingham危险评分低于对照组,血清HDL-C水平高于对照组(P<0.05)。结论氨氯地平阿托伐他汀钙治疗原发性高血压合并多重心血管疾病危险因素患者的临床疗效确切,降压、降脂效果明显。
Objective To investigate the clinical effect of amlodipine atorvastatin calcium on essential hypertension patients with multiple cardiovascular disease risk factors. Methods From March 2011 to February 2013,a total of 144 essential hypertension patients with multiple cardiovascular disease risk factors were selected in the Department of Cardiology,the Fifth Hospital of Xi′an,and they were divided into control group and treatment group,each of 72 cases. Patients of control group were given amlodipine tablets, while patients of treatment group were given amlodipine atorvastatin calcium tablets, both groups treated for 48 weeks. Blood pressure before treatment and after 4 weeks,24 weeks,48 weeks of treatment,blood lipid index （ including TC,TG,HDL-C,LDL-C） and Framingham risk score before and after treatment were compared between the two groups. Results No statistically significant differences of SBP or SDP was found between the two groups before treatment or after 4 weeks,24 weeks,48 weeks of treatment（P〉0. 05）;after 4 weeks,24 weeks,48 weeks of treatment,SBP and SDP of both groups were statistically significantly lower than those before treatment（P〈0. 05）. No statistically significant differences of serum TC,TG,HDL-C,LDL-C levels or Framingham risk score was found between the two groups before treatment（ P〉0. 05）;after treatment, serum TC, TG, LDL-C levels and Framingham risk score of treatment group were statistically significantly lower than those of control group,while serum HDL-C level of treatment group was statistically significantly higher than that of control group （ P〈0. 05 ）. Conclusion Amlodipine atorvastatin calcium has certain clinical effect in treating essential hypertension patients with multiple cardiovascular disease risk factors,is with effective antihypertensive effect and lipid- lowering effect.
出处
《实用心脑肺血管病杂志》
2015年第8期62-64,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
高血压
心血管疾病
氨氯地平
阿托伐他汀钙
治疗结果
Hypertension
Cardiovascular diseases
Amlodipine
Atorvastatin calcium
Treatment outcome
