摘要
目的观察与分析血清炎症因子对冠心病患者的影响,探讨曲美他嗪联合阿托伐他汀的临床疗效。方法选择医院2014年1月-2015年4月冠心病患者148例,随机分为对照组和治疗组各74例,检测两组患者治疗前后血清炎症因子,对照组患者给予常规治疗,治疗组患者在对照组治疗基础上应用曲美他嗪联合阿托伐他汀进行治疗,4周为一个疗程,评估临床治疗效果,数据采用SPSS11.0软件进行统计分析。结果患者治疗后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)治疗组分别为(19.52±2.44)ng/ml、(11.78±1.90)pg/ml和(15.20±1.97)mg/L,均低于对照组患者的(36.18±2.63)ng/ml、(19.93±2.06)pg/ml和(20.11±2.38)mg/L,两组患者治疗后血清炎性因子均低于治疗前,差异有统计学意义(P<0.05);治疗组患者治愈率为63.51%,明显高于对照组患者的52.70%,差异有统计学意义(P<0.05)。结论曲美他嗪联合阿托伐他汀治疗冠心病患者具有较好的临床疗效,可缩短患者心绞痛发作频率与持续时间,并能够显著降低患者血清炎症因子,促进患者的恢复。
OBJECTIVE To observe and analyze the influence of serum inflammatory factors on patients with coro‐nary heart diseases and to explore the clinical effect of Trimetazidine combined with Atorvastatin .METHODS Totally 148 patients with coronary heart disease were selected in the hospital from January .2014 to Apr .2015 , and they were randomly divided into the treatment group and the control group with 74 cases each .The control group was given routine treatment ,and the treatment group was given Trimetazidine combined with Atorvastatin treatment on the basis of the control group .Two groups were treated for four weeks as a treatment course .The clinical treatment effect was evaluated and SPSS 11 .0 was adopted for statistical analysis .RESULTS After the treatments ,the levels of TNF‐α,IL‐6 ,hs‐CRP in the treatment group were （19 .52 ± 2 .44） ng/ml ,（11 .78 ± 1 .90）pg/ml and（15 .20 ± 1 .97）mg/L respectively ,significantly lower than the control group of （36 .18 ± 2 .63） ng/ml ,（19 .93 ± 2 .06）pg/ml and（20 .11 ± 2 .38）mg/L .The level of serum inflammatory factors in both group de‐creased after the treatments and the differences were significant （P〈0 .05） .The curative rate in the treatment group was 63 .51% ,significantly higher than the control group with 52 .70% （P〈0 .05） .CONCLUSION Trimetaz‐idine combined with Atorvastatin have a good clinical efficacy in treating patients with coronary artery disease , they can shorten frequency and duration of angina pectoris ,and can significantly reduce the serum levels of inflam‐matory cytokines ,and promote the recovery of patients .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第20期4645-4646,4658,共3页
Chinese Journal of Nosocomiology
基金
桐乡市科技局基金资助项目(2011AY1120)
桐乡市卫生局基金资助项目(201303161)
关键词
冠心病
血清炎症因子
曲美他嗪
阿托伐他汀
Coronary heart disease
Serum inflammatory factors
Trimetazidine
Atorvastatin
