摘要
目的探究阿德福韦酯(ADV)联合拉米夫定(LAM)治疗乙肝病毒(HBV)感染后的肝硬化失代偿期的疗效和安全性。方法病例来源于陕西省安康市中心医院2010年1月至2012年9月收治确诊为乙肝肝硬化失代偿期病患112例,依照随机数字表法分为两组,每组56例,对应随机数字是奇数者为观察组,对应偶数者为对照组。对照组给予LAM治疗,观察组给予ADV联合LAM治疗,观测比较两组治疗前、治疗24周及48周时肝功能、治疗48周时Child-pugh评分及不良反应发生情况等指标。结果两组经治疗后肝功能均有显著改善(P<0.05),但观察组肝功能恢复较对照组更佳(P<0.05),差异有统计学意义;观察组治疗后Child-pugh评分与对照组比较差异有统计学意义(P<0.05);治疗48周时,观察组血清HBV DNA转阴率、HBe Ag转阴率较对照组上升明显(P<0.05),差异有统计学意义,并且两组患者治疗期间未见明显不良反应。结论 ADV联合LAM治疗乙肝肝硬化失代偿期病患疗效显著,安全性较高,能有效控制病情,临床意义重大。
Objective To explore the efficacy and safety of adefovir ester（ADV） combined therapy with lamivudine（LAM） on decompensated hepatitis B virus-related cirrhosis. Methods There were 112 patients treated in our hospital from January 2010 to September 2012 were diagnosed with hepatitis B cirrhosis of the liver decompensation period. They were divided into two groups according to random number table method, 56 cases in each group; the corresponding random number was odd number for the observation group, even as a control. The control group was given LAM therapy,and observation group was given ADV with LAM therapy.The liver function was observed in 24 and 48 weeks after treatment. The Child-pugh score metrics was recorded in 48 weeks after treatment and the adverse reactions was observed during the treatment. Results Two groups of liver function were improved significantly after treatment（P〈0.05）, but the observation group liver function recovered significantly better than that of the control group（P 〈0.05）; After treatment, the Child-pugh score of the ADV ＋LAM treatment group was significantly different from that of the control group（P〈0.05）.After 48 weeks of treatment, serum HBV DNA negative conversion rate, HBe Ag negative conversion rate of the observation group were significantly higher than those of the control group（P 〈0.05）, and had no obvious adverse reactions. Conclusion ADV combined with LAM treatment for hepatitis B cirrhosis of the liver decompensation period patients had obvious therapeutic effect, high safety, and no obvious adverse effect.
出处
《热带医学杂志》
CAS
2015年第9期1236-1238,1245,共4页
Journal of Tropical Medicine
