摘要
目的通过检测类风湿关节炎(RA)患者外周血清中CCL17的表达水平,探讨其在RA发病中的意义。方法采用酶联免疫吸附试验(ELISA)检测40例类风湿关节炎(RA)患者和20例正常对照组血清CCL17水平,记录被检者同批次实验室指标及相关临床表现,计算RA疾病活动评分(DAS28),并进行统计学分析。结果 RA组患者血清CCL17水平高于正常对照组,差异有统计学意义(P<0.05)。高度疾病活动RA患者组(DAS28≥5.1)血清CCL17水平高于中度疾病活动RA患者组(3.2≤DAS28<5.1),差异有统计学意义(P<0.05)。RA患者组血清CCL17水平与患者C反应蛋白、抗环瓜氨酸多肽抗体、血小板计数呈正相关,差异有统计学意义(P<0.05)。结论 RA患者外周血清CCL17水平较正常对照组升高,且与疾病活动指标具有一定的相关性,提示CCL17可能参与了RA的发生及疾病进展过程。
Objective To investigate the expression levels of serum CCL17 in patients with rheumatoid arthritis（RA）,so as to explore its clinical significance. Methods The expression of serum CCL17 was measured by ELISA in 40 RA patients and 20 normal individuals. The correlation of serum levels of CCL17 with clinical active index was analyzed. Results The serum level of CCL17 in RA patients was significantly higher than those in normal controls（P〈0.05）. Serum CCL17 level in patient with advanced disease（DAS28≥5.1）was higher than those in medium disease activity group（3.2≤DAS285.1）（P〈0.05）. The serum level of CCL17 in RA was obviously correlated with CRP,anti-CCP,the count of PLT（P〈0.05）.Conclusion High level of CCL17 expression was found in serum of RA patients. Our results also proved that serum level of CCL17 has certain correlation with disease activity index in RA patients,which indicates CCL17 may be involved in the process of the pathogenesis and progression of RA.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2015年第10期913-916,920,共5页
Journal of China Medical University
基金
辽宁省科学技术计划项目(2014225017)
