摘要
目的探讨中老年女性甲状腺结节与中心性肥胖的相关性。方法选取2012年1—12月于新疆医科大学第一附属医院健康体检中心进行体检的中老年女性551例为研究对象,根据甲状腺超声检查结果将受试者分为甲状腺结节组(282例)和非甲状腺结节组(269例)。测量受试者身高、体质量、腹围、收缩压、舒张压及空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)等生化指标。结果非甲状腺结节组与甲状腺结节组体质量、身高、BMI及其分级、收缩压、舒张压、高血压发病率、FBG、TC、HDL-C、LDL-C和血脂异常率比较,差异均无统计学意义(P>0.05)。甲状腺结节组年龄、腹围、中心性肥胖发病率、糖尿病发病率及TG水平高于非甲状腺结节组,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄〔OR=1.04,95%CI(1.02,1.07),P=0.01〕和中心性肥胖〔OR=1.76,95%CI(1.14,2.73),P=0.01〕进入回归方程,是中老年女性发生甲状腺结节的影响因素。腹围判断中老年女性发生甲状腺结节的ROC曲线下面积为0.559(P=0.017),最佳分界点为82 cm,灵敏度和特异度分别为69%、58%。结论中心性肥胖是中老年女性发生甲状腺结节的危险因素,采用腹围判断中老年女性甲状腺结节发生的准确性较差。
Objective To investigate the correlation between thyroid nodule and central obesity in middle and old aged women. Methods From January to December in 2012,we enrolled 551 middle and old aged women who received physical examination in the Health Examination Center of the First Affiliated Hospital of Xinjiang Medical University. According to the results of thyroid ultrasound examination,the subjects were divided into two groups： thyroid nodule group（ n = 282） and non thyroid nodule group（ n = 269）. Human body indexes,such as height,baby mass,abdomen circumference,SBP and DBP,and biochemical indexes,such as FBG,TG,TC,HDL-C and LDL-C,of the subjects were measured. Results The two groups were not significantly different（ P〉0. 05） in body mass, height, BMI and its grading, SBP, DBP, hypertension incidence,FBG,TC,HDL-C,LDL-C and dyslipidemia ratio. The thyroid nodule group was higher（ P〈0. 05） than non thyroid group in age, abdomen circumference, central obesity incidence, diabetes incidence and TG level. Logistic regression analysis showed that age 〔OR = 1. 04,95% CI（ 1. 02,1. 07）,P = 0. 01〕and central obesity 〔OR = 1. 76,95% CI（ 1. 14,2. 73）,P = 0. 01〕entered regression equation,which indicated that they are influencing factors for thyroid nodule in middle and old aged women. The AUC of judging thyroid nodule in middle and old aged women by abdomen circumference was 0. 559（ P =0. 017）,with an optimum cut-off point of 82 cm, and the sensitivity and specificity were 69% and 58% respectively.Conclusion Central obesity is a risk factor for thyroid nodule in middle and old aged women. The judgment of thyroid nodule in middle and old aged women by abdomen circumference don＇t have a good accuracy.
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第29期3551-3554,共4页
Chinese General Practice
基金
乌鲁木齐市科学技术计划项目(F131310001)
新疆医科大学教育改革项目(YG2013029
YG2013004)
