摘要
目的:观察早期康复治疗对脑卒中后抑郁患者神经功能及细胞因子的影响。方法:110例脑卒中后抑郁患者,随机分为康复组和对照组各55例,2组均接受神经内科常规治疗,康复组在此基础上给予早期康复治疗,治疗前后采用汉密尔顿抑郁量表(HAMD)评定抑郁程度,简式Fugl-Meyer评分(FMA)评定运动功能,改良Barthel指数(MBI)评定日常生活活动能力,放射免疫法检测血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)水平。结果:治疗4周后,2组HAMD总分及各因子评分均较治疗前明显降低(P<0.05),且康复组更低于对照组(P<0.05);2组FMA及MBI评分均较治疗前明显提高(P<0.05),且康复组更高于对照组(P<0.05);2组血清IL-1、IL-6、TNF-α含量均较治疗前明显降低(P<0.05),且康复组更低于对照组(P<0.05)。结论:早期康复治疗对脑卒中后抑郁有显著的改善作用,可能通过降低脑卒中后抑郁患者患者血清细胞因子水平达到治疗效果。
Objective： To observe the influence of the early rehabilitation treatment on neural function and cyto- kines in patients with depression after stroke. Methods： 110 patients with depression after stroke were randomly di- vided into rehabilitation group and the control group, 55 cases in each group. The two groups were treated with rou- tine treatment in the Department of Neurology. Moreover, the rehabilitation group received early rehabilitation treatment. Before and after treatment, the degree of depression was assessed by Hamilton Depression Rating Scale （HAMD）, the motor function was assessed by Fug-meyer score （FMA）, and the ability of daily life was assessed by Modified Barthel Index （MBI）. The levels of serum interleukin-1 （IL-1）, IL-6 and tumor necrosis factor （TNF-α） were analyzed using radioimmunoassay. Results： Four weeks after treatment, HAMD score and the score of each factor of two groups were significantly lower than those before treatment （P〈0. 05）, and the score of rehabilitation group was significantly lower than that of control group （P〈0. 05）. The FMA and MBI scores were significantly increased in two groups after treatment （P〈0. 05）, and those in rehabilitation group were significantly higher than in the control group （P〈0. 05）. The levels of serum IL-1, IL-6 and TNF-α in two groups were significantly lower after treatment than those before treatment （P〈0.05）, and those in rehabilitation group were significantly lower than in the control group （P〈0. 05）. Conclusion： Early rehabilitation therapy can significantly improve the depres- sion after stroke, which may be achieved by lowering the level of serum cytokines.
出处
《中国康复》
2015年第5期346-348,共3页
Chinese Journal of Rehabilitation
基金
黄冈市科技研究与开发计划项目(黄科字【2012】62号)
关键词
脑卒中
抑郁
早期康复
stroke
depression
early rehabilitation
