摘要
遗传学与表观遗传学的累积性改变是肿瘤发生、发展的主要原因。抑癌基因启动子甲基化已成为许多肿瘤发生和发展的关键因素。RASSF10位于人染色体11p15.2上,它是通过结构预测获得的与其他氨基端RASSF家族同源的成员之一,其氨基端在人、非洲爪蟾和果蝇中具有一个保守的结构域,能够抑制细胞有丝分裂。RASSF10在结肠癌、胃癌、食管癌、甲状腺癌、白血病等多种肿瘤中频繁发生甲基化,且其表达受启动子区甲基化的调控。RASSF10甲基化是潜在的结肠癌、胃癌等肿瘤的诊断、预后及化疗敏感性的标志物。RASSF10通过调控Wnt、P53通路而抑制肿瘤的生长。
Accumulation of genetic and epigenetic changes involve in the carcinogenesis and progression of human cancers. DNA methylation is one of the most studied epigenetic changes in human cancer. The human RASSF10 gene is located on chromosome 11p15. 2 and was first described from a predicted sequence with homology to RASSF9. RASSF10 is frequently methylated in human colorectal,esophageal,gastric and thyroid cancer,as well as leukemia. RASSF10 methylation may serve as diagnostic,predictive and chemo-sensitive markers in colorectal and gastric cancer. RASSF10 suppresses tumorigenesis and progression by regulating Wnt and P53 signaling.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第10期1260-1263,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
国家重大科学研究计划(973计划No.2012CB934002
2015cb553904)
国家高技术研究发展计划(863计划No.SS2012AA020314
SS2012AA020821
SS2012AA020303)
国家重大科学仪器设备开发专项(Grant No.2011YQ03013405)
国家自然科学基金(NSFC No.81402345
81121004
81490753)
