摘要
文章概述了从海胆壳棘中发现的一些具代表性、结构独特、有生物活性的天然产物:萘醌类色素、苯醌类色素、类胡萝卜素、具有离子通道调控与抗肿瘤及免疫调节活性的蛋白质等,就相应分离纯化手段、合成路线、生物活性与潜在药用价值作简要概述,并简述了基因测序与生物信息学分析在海胆壳棘功能活性蛋白研究上的应用以及传统中药实践中海胆壳棘的功效等内容。
Marine natural products vary from small molecules to high molecular weight proteins and display u-nique chemical and biological features of scientific interest. Many of these substances can serve as useful re-search tools or molecular models for the design of new drugs. This review summarizes the current knowledge of the following biologically active components isolated and characterized from the test, spines and pedicellaria of sea urchin： naphthoquinone pigments, benzoquinone pigment, carotenoid, ion channel-targeted proteins, anticancer and immunologically active proteins. Other topics covered include the use of bioinformatics analysis in investigating protein profiling and the application of sea urchin test and spines in traditional Chinese medi-cine.
出处
《福建水产》
2015年第5期415-425,共11页
Journal of Fujian Fisheries
基金
省属公益类科研院所基本科研专项(2014R1003-6)
海洋产业核心和关键技术攻关项目(14CZP041HJ15)
关键词
海胆壳棘
色素
蛋白质
生物活性
药用价值
sea urchin test spines and pedicellaria
pigments
proteins
biological activities
pharmaceuti-cal significance
