摘要
人中性粒细胞肽（HNP）-l-3是人体内的一种天然防御蛋白混合物，对诸多细菌、真菌和病毒以及癌细胞有强烈的杀灭或抑制作用。HNP-1～3在宿主儿童唾液中的表达水平的高低与儿童自身的患龋风险明显相关，其在唾液中的质量浓度也直接影响着宿主口腔生态环境的变化，对口腔主要致龋菌也有明显的抑制作用。在未来开展的儿童龋病风险预测工作中，以HNP-1～3作为一种重要的检测指标，不仅可使儿童龋病风险预测工作更为准确，还能使有限的医疗资源得到高效合理的利用。
Human neutrophil peptide（HNP）-1-3 is a natural defense protein that exerts strong fatal or inhibitory effects on bacteria, fungi, viruses, and cancer cells. The expression level of HNP-1-3 in the saliva of children is significantly correlated with their caries risk. Its mass concentration in the saliva directly influences the oral ecological environment of the host. This protein can significantly inhibit majorcariogenic bacteria. HNP-1-3 is an important indicator of caries risk and can be effectively utilized in caries risk prediction in children, especially in those with limited medical resources.
出处
《国际口腔医学杂志》
CAS
北大核心
2015年第6期699-702,共4页
International Journal of Stomatology
基金
云南省科技计划项目联合专项基金(2009CD)
关键词
抗菌肽
人中性粒细胞肽
生物学活性
患龋风险
antimicrobial peptide
human neutrophil peptide
biological activity
caries risk
