摘要
目的:探讨超声联合糖链抗原125(CA125)、人附睾蛋白4(HE4)、糖链抗原19-9(CA19-9)三种血清肿瘤标志物对卵巢癌的诊断价值。方法:将111例经手术病理诊断证实的卵巢肿块患者根据诊断结果范围良性组(66例)和恶性组(45例),另选择同期体检的健康女性42例作为对照组,对所有患者进行二维及彩色多普勒超声检查并将检查结果与病理诊断结果作对照,测定三组受试者血清CA125、HE4和CA19-9水平。评价超声及血清肿瘤标志物单项及联合检测对卵巢癌的诊断价值。结果:恶性组血清肿瘤标志物CA125、HE4和CA19-9均显著高于良性组和对照组(均P<0.05);恶性组患者阻力指数(RI)和搏动指数(PI)均显著低于良性组患者(均P<0.05);超声诊断卵巢癌的敏感度尚可,但特异度较低,而血清肿瘤标志物诊断卵巢癌的特异度较高,超声联合三种肿瘤标志物诊断卵巢癌的敏感度为90.91%,特异度为77.78%。结论:超声联合血清肿瘤标志物CA125、HE4和CA19-9可以提高卵巢癌诊断的敏感度,具有重要的临床意义。
Objective：To explore the value of ultrasound combined with serum tumor markers carbohydrate antigen 125（CA125）,Human epididymis protein 4（HE4）and carbohydrate antigen 19-9（CA19-9）detection in the diagnosis of ovarian cancer.Methods：A total of 111 cases of ovarian tumors confirmed by surgery pathology diagnosis were divided into benign group（n=66cases）and malignant group（n=45cases）according to diagnosis.Another 42 cases of healthy women were selected as control group during the same period.All subjects underwent two dimensional and color doppler flow imaging examination and the results were compared with pathological diagnosis.Serum CA125,HE4 and CA19-9levels in three groups were detected in order to evaluate the value of serum cancer markers detections alone or in combination with two dimensional andcolor doppler flow imaging examination in diagnosis of ovarian cancer.Results：The serum tumor marker CA125,HE4 and CA19-9levels in malignant group were significantly higher than that of benign group and the control group,the difference was statistically significant（all P〈0.05）,while there were no statistical significance differences between levels of benign group and the control group（P〉0.05）.The resistance index（RI）and pulse index（PI）in malignant patients were significantly lower than that of benign group,the difference was statistically significant（all P〈0.05）.The sensitivity of the ultrasonic examination was good but the specificity was low.While the detection of tumor markers showed high specificity.The sensitivity of serum cancer markers detection in combination with two dimensional and color doppler flow imaging examination was 90.91%,and the specificity was 77.78%.Conclusion：Detection of CA125,HE4 and CA19-9can improve the diagnosis sensitivity of ovarian cancer.
出处
《海南医学院学报》
CAS
2015年第12期1707-1709,1712,共4页
Journal of Hainan Medical University
基金
陕西省科学技术发展研究项目(2012R12-487)~~
关键词
卵巢癌
超声检查
糖链抗原125
人附睾蛋白4
糖链抗原19-9
Ovarian cancer
Ultrasound examination
Carbohydrate antigen 125
Human epididymis protein 4
Carbo-hydrate antigen 19-9
