摘要
目的对比阿立哌唑与奋乃静治疗酒精中毒性精神障碍的临床疗效与安全性。方法将我院2013年5月至2014年10月期间收治的162例酒精中毒性精神障碍患者平均分为两组,观察组采用阿立哌唑治疗,对照组采用奋乃静治疗。对比两组患者的临床疗效、认知情况及副反应。结果两组患者的临床疗效无显著差异(P>0.05)。治疗6周后,观察组患者的MMSE评分明显优于对照组(P<0.01),不良反应明显少于对照组(P<0.01)。结论阿立哌唑治疗酒精中毒性精神障碍的疗效可靠,且安全性较奋乃静更高,可作为治疗酒精中毒性精神障碍的常规药物。
Objective To compare the clinical effect and safety of aripiprazole and perphenazine in the treatment of mental disorder induced by alcoholism. Methods 162 patients with mental disorder induced by alcoholism who were treated in our hospital from 2013 May to 2014 October were divided into two groups,patients in observation group were cured with aripiprazole,whereas patients in control group were treated with perphenazine.Compare the clinical effect,cognitive competence and adverse reaction of these two groups. Results There was no significant difference between the clinical effect of these two groups（ P〉0. 05）. After 6 weeks of treatment,the MMSE scores of observation group were markedly better than control group（ P〈0. 01）,adverse reaction rate was significantly lower than control group（ P〈0. 01）. Conclusion The clinical effect of aripiprazole on mental disorder induced by alcoholism was reliable,its safety is higher than perphenazine,thus aripiprazole could be used as a routine medicine in curing mental disorder induced by alcoholism.
出处
《国际精神病学杂志》
2015年第5期20-23,共4页
Journal Of International Psychiatry
关键词
酒精中毒性精神障碍
阿立哌唑
奋乃静
Mental disorder induced by alcoholism
Aripiprazole
Perphenazine
