摘要
前列腺癌(PCa)是全球男性最常见的恶性肿瘤之一,同时也是癌症死亡的常见原因。如今血清标志物的检测已经在很大程度上提高了PCa的早期诊断,然而其潜在的分子机制一直没有完全被人们认识。长链非编码RNA(lncRNA)在PCa中的潜在作用体现在致癌和抑癌两个方面。LncRNA在绝大多数PCa中异常表达。本文将综述lncRNA在PCa中的异常表达,并讨论其在PCa的诊断、预测、预后、转移以及潜在临床治疗方面所扮演的新角色。
Prostate cancer（PCa）is one of the most common malignant tumors as well as a frequent cause of cancer-related mortality in men worldwide.The test of serum markers has dramatically improved the early diagnosis of PCa,but its underlying molecular mechanisms are not yet completely identified.Long noncoding RNA（lncRNA）is emerging as a new player in the PCa paradigm demonstrating its potential roles in both oncogenic and tumor suppressive pathways.LncRNA is frequently aberrantly expressed in the majority of PCa cases.This review highlights recent findings of the aberrant expression of lncRNA in PCa and discusses its novel roles in the diagnosis,prediction,prognosis,metastasis,and potential clinical treatment of PCa.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2015年第10期945-948,共4页
National Journal of Andrology
基金
江苏省“六大人才高峰”高层次人才项目资助方案(2012-WSN-020)
江苏省“333高层次人才培养工程”(2011,Ⅲ-2610)
江苏省科技计划在研项目(BK20131442)~~
