摘要
目的:探讨抗α-fodrin抗体在干燥综合征(sjgren’syndrome,SS)中的诊断意义及与临床之间的相关性。方法:应用德国AESKULISA公司的抗α-fodrin抗体ELISA检测试剂盒检测原发干燥综合征(primary sjgren's syndrome,p SS)125例,继发干燥综合征(secondary sjgren's syndrome,s SS)30例,类风湿关节炎(RA)71例,系统性红斑狼疮(SLE)50例,干燥综合征可能4例的血清标本,并分析其结果与SS的临床表现、实验室检查等的相关性。结果:(1)抗α-fodrin抗体在SS、pSS、sSS中的阳性率分别为:27.7%(43/155)、24.8%(31/125)、40%(12/30),在RA、SLE中的阳性率为19.7%(14/71)和24%(12/50),抗α-fodrin抗体在SS、pSS、sSS与RA、SLE之间差别无统计学意义;(2)抗α-fodrin抗体是否阳性与肺间质改变、肾小管酸中毒、神经系统损伤、血小板减少、白细胞减少相关性不强;抗α-fodrin抗体是否阳性与血沉增快、C反应蛋白升高、RF、ANA、抗SSA抗体、抗SSB抗体之间无明显相关性;(3)在4例诊断干燥综合征可能的患者中,有3例出现了抗α-fodrin抗体的阳性。结论:抗α-fodrin抗体在SS中出现的阳性率不高,抗α-fodrin抗体与SS患者的临床表现、脏器受累及其他自身抗体均无明显相关性。但在4例诊断干燥综合征可能的患者中,有3例出现了抗α-fodrin抗体的阳性,提示可能抗α-fodrin抗体在SS的早期出现。总之,抗α-fodrin抗体阴性不能除外SS,但抗α-fodrin抗体阳性可能有助于SS的诊断。
Objective： To explore the significance of anti-α-fodrin antibody in the diagnosis of Sjogren＇s syndrome and its correlation with clinical manifestations. Methods： Recombinant human α-fodrin was used as envelope antigen in enzyme-linked immunosorbent assay（ ELISA） to detect the relatively specific autoantibody in sera of 125 primary SS,30 secondary SS with RA or SLE,71 rheumatoid arthritis（ RA）,50 systemic lupus erythematosus（ SLE）,4 possible of SS. Results：（ 1） Anti-α-fodrin antibody was present in27. 7%（ 43 /155） of SS patients,24. 8%（ 31 /125） of primary SS patients,40%（ 12 /30） of secondary SS patients,and 19. 7%（ 14 /71） of RA patients,24%（ 12 /50） of SLE patients. It showed no significant correlation between primary and secondary SS,as well as SS compared with RA and SLE patients.（ 2） The presence of anti-α-fodrin antibody had no significant correlation with clinical manifestation or other autoantibody.（ 3） Anti-α-fodrin antibody was positive in 3 patients,of whom 4 had possible diagnosis of SS.Conclusion： The results show that anti-α-fodrin antibody was low in SS,but it may be present in early SS. So negative anti-α-fodrin antibody cannot exclude SS,but the presence of anti-α-fodrin antibody may be helpful the diagnosis of SS.
出处
《川北医学院学报》
CAS
2015年第5期659-662,共4页
Journal of North Sichuan Medical College
