针刺治疗膝骨性关节炎的临床试验结果与对照组设置相关性研究的系统分析被引量：5

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摘要为了评估针刺治疗膝骨性关节炎（Knee Osteoarthritis,KOA）的临床试验结果是否与试验对照组的设置方式相关,本次系统分析共检索7个数据库,纳入21篇2004~2014年间SCI杂志出版的针刺治疗膝骨性关节炎的随机对照试验（RCTs）文献,对等待组（Wait-list control,WL）、非刺入性假针刺组（Non-insertion sham acupuncture control,NP）和刺入性假针刺组（Needle-insertion sham acupuncture control,SN）等三种不同对照组设置方式的试验结果进行统计,结果显示三种对照组设置方式的试验结果阳性率依次为92%（WL）,67%（NP）和50%（SN）,充分说明针刺治疗膝骨性关节炎的临床试验结果与试验对照组的设置方式密切相关。假针刺组（尤其是刺入性假针刺组）的试验结果阳性率较低的原因可能是由针刺部位的差异、刺激方式的差异（如不同的电针参数）等针刺的特异性因素引起,也可能与非特异性的弥散性伤害抑制控制作用（Diffuse noxious inhibitory control,DNIC）产生和正常针刺相似的生理效应有关。在未来的研究中,对照组设置方式的选择仍需根据试验目的的不同进行更多深入探讨,这对针刺临床试验模式的建立尤为重要。

作者张晓雨宁志鹏陈海勇劳力行

机构地区香港大学中医药学院

出处《中国疼痛医学杂志》 CAS CSCD 2015年第10期732-737,共6页 Chinese Journal of Pain Medicine

关键词针刺膝骨性关节炎对照组设置系统分析

分类号 R246.9 [医药卫生—针灸推拿学]

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1Yoshinori Mikashima,Tadashi Takagi,Taisuke Tomatsu,Mariko Horikosh,Katsunori Ikari,Shigeki Momohara.Efficacy of acupuncture during post-acute phase of rehabilitation after total knee arthroplasty[J].Journal of Traditional Chinese Medicine,2012,32(4):545-548. 被引量：12
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