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紫癜清颗粒对HSP患者CD4^+ CD25^+ Tregs细胞的影响 被引量：1

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摘要 目的探讨紫癜清颗粒对过敏性紫癜(HSP)患者的临床疗效及外周血CD4+CD25+调节性T细胞、其转录因子FOXP3表达的影响。方法纳入60例确诊为HSP患者,随机分为两组,治疗组予以紫癜清颗粒(A组),对照组予以激素联合抗组胺药物(B组);两周为1个疗程,共观察4周,随访半年,采用流式细胞术检测外周血CD4+CD25+Treg、转录因子FOXP3的表达,同期选10例健康人作为正常对照。结果治疗组有效率与对照组相当(P>0.05),但复发率较对照组减低(P<0.01);A、B组治疗前外周血CD4+CD25+Treg及CD4+CD25+FOXP3+表达比例较健康对照组明显降低(P<0.01);紫癜清颗粒治疗后患者外周血CD4+CD25+Treg及CD4+CD25+FOXP3+比例增高,与对照组治疗后患者外周血CD4+CD25+Treg及CD4+CD25+FOXP3+的表达相比,无统计学意义(P>0.05),但表达比例较对照组高。结论 1治疗组总有效率为93.33%,对照组总有效率为96.66%,说明中药汤剂紫癜清颗粒与西医传统治疗方案激素联合抗组胺药物疗效相当,但其复发率及临床副作用较西药治疗都明显减少;2A、B组治疗前CD4+CD25+Treg的表达低于正常,说明调节性T细胞可能参与了HSP的发病,而治疗后CD4+CD25+Treg及CD4+CD25+FOXP3+的表达增高,可能是紫癜清颗粒治疗HSP有效的原因。
作者 郝晶 孙凤 罗正凯 雍彦礼 赵伟 王金环 常亚娟 田飞 梅婷
机构地区 黑龙江中医药大学附属第一医院 黑龙江中医药大学
出处 《时珍国医国药》 CAS CSCD 北大核心 2015年第10期2380-2382,共3页 Lishizhen Medicine and Materia Medica Research
基金 黑龙江省自然科学基金(No.D201153) 黑龙江中医药管理局科研项目(No.ZHY10-Z41)
关键词 过敏性紫癜 紫癜清颗粒 CD4+CD25+TREG CD4+CD25+FOXP3+
分类号 R285.6 [医药卫生—中药学]
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参考文献9

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二级参考文献124

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时珍国医国药
2015年 第10期

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