摘要
富含炎症细胞、细胞因子、趋化因子的炎症微环境可诱发细胞的增殖和突变,从而为肿瘤细胞的生长、扩散以及免疫逃避提供了可能。白细胞介素6(IL-6)是一种由免疫细胞产生的多功能炎性细胞因子,它在机体炎症反应,免疫应答以及造血调控中都扮演着重要角色。现在越来越多的研究发现肿瘤炎症微环境中的IL-6在许多肿瘤的发生发展中都起着关键作用,笔者就近年来IL-6与消化道肿瘤关系的研究进展进行综述。
The inflammatory microenvironment that is enriched with inflammatory cells,cytokines and chemokines can induce cell proliferation and mutation,and thereby provides possibility of growth,migration and immune evasion for tumors.Interleukin-6（IL-6） is a multifunctional inflammatory factor produced by immune cells,which plays an important role in the inflammatory reactions,immune responses and hematopoietic regulation.More and more studies have found that IL-6 plays a key role in the development and progression of many cancers.In this paper,the authors address the recent progress concerning the relationship between IL-6 and digestive tract tumors.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2015年第10期1457-1462,共6页
China Journal of General Surgery
关键词
胃肠肿瘤
炎症
白细胞介素6
综述文献
Gastrointestinal Neoplasms
Inflammation
Interleukin-6
Review
